| http://dbpedia.org/ontology/abstract
|
The translationally controlled tumour prot … The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. TCTP is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TCTP production is thought to be controlled at the translational as well as the transcriptional level.onal as well as the transcriptional level.
|
| http://dbpedia.org/ontology/omim
|
600763
|
| http://dbpedia.org/ontology/symbol
|
FLJ27337,tpt1,HRF, p02, p23, p21
, TCTP
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1h7y_EBI.jpg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
11488155
|
| http://dbpedia.org/ontology/wikiPageLength
|
14557
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1075713132
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Tumor_reversion +
, http://dbpedia.org/resource/Secondary_structure +
, http://dbpedia.org/resource/Laurent_Susini +
, http://dbpedia.org/resource/Cell_growth +
, http://dbpedia.org/resource/Cancer +
, http://dbpedia.org/resource/Gene_expression +
, http://dbpedia.org/resource/Chaperone_%28protein%29 +
, http://dbpedia.org/resource/Molecular_chaperone +
, http://dbpedia.org/resource/Transcription_%28genetics%29 +
, http://dbpedia.org/resource/P53_tumour_suppressor +
, http://dbpedia.org/resource/Plants +
, http://dbpedia.org/resource/Class_%28biology%29 +
, http://dbpedia.org/resource/Mammalia +
, http://dbpedia.org/resource/Uterus +
, http://dbpedia.org/resource/Allergic_reaction +
, http://dbpedia.org/resource/Embryo_development +
, http://dbpedia.org/resource/Regulation_of_gene_expression +
, http://dbpedia.org/resource/Hydrophilic +
, http://dbpedia.org/resource/Cytoskeleton +
, http://dbpedia.org/resource/Tumour +
, http://dbpedia.org/resource/Vitamin +
, http://dbpedia.org/resource/Sequence_%28biology%29 +
, http://dbpedia.org/resource/Protein +
, http://dbpedia.org/resource/Gene_regulation +
, http://dbpedia.org/resource/Translation_%28biology%29 +
, http://dbpedia.org/resource/Apoptosis +
, http://dbpedia.org/resource/Beta-sheets +
, http://dbpedia.org/resource/Protein-protein_interaction +
, http://dbpedia.org/resource/Cell_%28biology%29 +
, http://dbpedia.org/resource/Eukaryote +
, http://dbpedia.org/resource/Tubulin +
, http://dbpedia.org/resource/Category:Protein_domains +
, http://dbpedia.org/resource/Calcium +
, http://dbpedia.org/resource/Molecular_binding +
, http://dbpedia.org/resource/Actin +
, http://dbpedia.org/resource/Homology_%28biology%29 +
, http://dbpedia.org/resource/Mcl-1 +
, http://dbpedia.org/resource/Cell_proliferation +
, http://dbpedia.org/resource/Bcl-xL +
, http://dbpedia.org/resource/Cell_cycle +
, http://dbpedia.org/resource/Trypanosoma_brucei +
, http://dbpedia.org/resource/Homo_sapiens +
, http://dbpedia.org/resource/N-terminal +
, http://dbpedia.org/resource/Alpha_helices +
, http://dbpedia.org/resource/Eukaryotes +
, http://dbpedia.org/resource/Heat_shock +
, http://dbpedia.org/resource/Binding_%28molecular%29 +
, http://dbpedia.org/resource/Bcl-2-associated_X_protein +
, http://dbpedia.org/resource/Guanine +
, http://dbpedia.org/resource/Tumor +
, http://dbpedia.org/resource/Translational +
|
| http://dbpedia.org/property/caption
|
translationally controlled tumor-associated protein p23fyp from schizosaccharomyces pombe
|
| http://dbpedia.org/property/interpro
|
IPR018105
|
| http://dbpedia.org/property/name
|
TCTP
, Translationally Controlled Tumour Protein
|
| http://dbpedia.org/property/omim
|
600763
|
| http://dbpedia.org/property/pfam
|
PF00838
|
| http://dbpedia.org/property/pfamClan
|
CL0080
|
| http://dbpedia.org/property/prosite
|
PDOC00768
|
| http://dbpedia.org/property/scop
|
2.209032E8
|
| http://dbpedia.org/property/symbol
|
TCTP
, FLJ27337,tpt1,HRF, p02, p23, p21
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Infobox_protein +
, http://dbpedia.org/resource/Template:Infobox_protein_family +
, http://dbpedia.org/resource/Template:InterPro_content +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Protein_domains +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Translationally_controlled_tumour_protein?oldid=1075713132&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1h7y_EBI.jpg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Translationally_controlled_tumour_protein +
|
| http://xmlns.com/foaf/0.1/name
|
Translationally Controlled Tumour Protein
|
| owl:sameAs |
http://yago-knowledge.org/resource/Translationally_controlled_tumour_protein +
, https://global.dbpedia.org/id/2L7D8 +
, http://dbpedia.org/resource/Translationally_controlled_tumour_protein +
, http://rdf.freebase.com/ns/m.02rfkt5 +
, http://www.wikidata.org/entity/Q24775511 +
|
| rdf:type |
http://dbpedia.org/class/yago/Part113809207 +
, http://dbpedia.org/class/yago/Relation100031921 +
, http://dbpedia.org/class/yago/WikicatProteinDomains +
, http://dbpedia.org/class/yago/Situation113927383 +
, http://dbpedia.org/class/yago/Environment113934596 +
, http://dbpedia.org/class/yago/Macromolecule114944888 +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/class/yago/Matter100020827 +
, http://dbpedia.org/class/yago/Protein114728724 +
, http://dbpedia.org/class/yago/OrganicCompound114727670 +
, http://dbpedia.org/class/yago/Material114580897 +
, http://dbpedia.org/class/yago/Compound114818238 +
, http://dbpedia.org/class/yago/Chemical114806838 +
, http://dbpedia.org/class/yago/Substance100019613 +
, http://dbpedia.org/class/yago/Thing100002452 +
, http://dbpedia.org/class/yago/Molecule114682133 +
, http://dbpedia.org/class/yago/Unit109465459 +
, http://dbpedia.org/class/yago/Sphere114514039 +
, http://www.wikidata.org/entity/Q206229 +
, http://dbpedia.org/class/yago/PhysicalEntity100001930 +
, http://dbpedia.org/ontology/Biomolecule +
, http://dbpedia.org/class/yago/Attribute100024264 +
, http://dbpedia.org/class/yago/State100024720 +
, http://dbpedia.org/ontology/Protein +
, http://www.wikidata.org/entity/Q8054 +
|
| rdfs:comment |
The translationally controlled tumour prot … The translationally controlled tumour protein, commonly known as TCTP, is a highly conserved protein among many eukaryotic organisms. TCTP is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TCTP) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is indimalarial compound artemisinin, and is ind
|
| rdfs:label |
Translationally controlled tumour protein
|
