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http://dbpedia.org/resource/Moroidin
http://dbpedia.org/ontology/abstract Moroidin is a biologically active compound … Moroidin is a biologically active compound found in the plants Dendrocnide moroides and Celosia argentea. It is a peptide composed of eight amino acids, with unusual leucine-tryptophan and tryptophan-histidine cross-links that form its two rings. Moroidin has been shown to be at least one of several bioactive compounds responsible for the painful sting of the Dendrocnide moroides plant. It also has demonstrated anti-mitotic properties, specifically by inhibition of tubulin polymerization. Anti-mitotic activity gives moroidin potential as a chemotherapy drug, and this property combined with its unusual chemical structure has made it a target for organic synthesis.as made it a target for organic synthesis.
http://dbpedia.org/ontology/iupacName (8S,9S,12S,15S,18S,21S,27S)-21-[3-(diamino … (8S,9S,12S,15S,18S,21S,27S)-21-[3-(diaminomethylideneamino)propyl]-12-(2-methylpropyl)-10,13,16,19,22,25-hexaoxo-9-{[(2S)-5-oxopyrrolidine-2-carbonyl]amino}-8,15-di(propan-2-yl)-2,11,14,17,20,23,26,30,32-nonazapentacyclo[16.14.2.13,7.129,32.04,33]hexatriaconta-1(33),3,5,7(36),29(35),30-hexaene-27-carboxylic acid7(36),29(35),30-hexaene-27-carboxylic acid
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http://dbpedia.org/property/caption A simplified version of Castle and coworker's partial synthesis of the Leu-Trp crosslink. The linkage is achieved in the second step with radical conjugate addition. , Simplified reaction scheme for the formation of the Leu-Trp crosslink from Chen and coworkers. The link is formed in one step under palladium catalysis. , Reaction scheme from Jia and coworkers showing the synthesis of the Leu-Trp crosslink. The first step shows the asymmetric Michael addition that forms the crosslink, followed by bromination that allows substituents to be added in subsequent steps.
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http://dbpedia.org/property/footer Examples of synthetic approaches to the Leu-Trp crosslink in the left-hand ring of moroidin.
http://dbpedia.org/property/image Chen and coworkers partial synthesis of celogentin C.png , Jia and coworkers partial synthesis of celogentin C.png , Castle and co partial synthesis celogentin C.png
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rdfs:comment Moroidin is a biologically active compound … Moroidin is a biologically active compound found in the plants Dendrocnide moroides and Celosia argentea. It is a peptide composed of eight amino acids, with unusual leucine-tryptophan and tryptophan-histidine cross-links that form its two rings. Moroidin has been shown to be at least one of several bioactive compounds responsible for the painful sting of the Dendrocnide moroides plant. It also has demonstrated anti-mitotic properties, specifically by inhibition of tubulin polymerization. Anti-mitotic activity gives moroidin potential as a chemotherapy drug, and this property combined with its unusual chemical structure has made it a target for organic synthesis.as made it a target for organic synthesis.
rdfs:label Moroidin
rdfs:seeAlso http://dbpedia.org/resource/Dendrocnide_moroides +
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