| http://dbpedia.org/ontology/abstract
|
Регуляторные факторы интерферонов — белки, … Регуляторные факторы интерферонов — белки, которые регулируют транскрипцию интерферонов. (см регуляцию экспрессии генов) Они используются в . Регуляторные факторы интерферона содержат консервативную область около 120 аминокислот, содержащиеся в , которая специфически связывается с последовательностью интерферонного консенсуса (ICS), нкаходящегосяся генами интерферона. Остальные части последовательности регуляторного фактора интерферона изменяются в зависимости от точной функции белка.тся в зависимости от точной функции белка.
, Interferon regulatory factors (IRF) are pr … Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. Some viruses have evolved defense mechanisms that regulate and interfere with IRF functions to escape the host immune system. For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. In addition, the expression of IRF genes is under epigenetic regulation by promoter DNA methylation.ic regulation by promoter DNA methylation.
|
| http://dbpedia.org/ontology/symbol
|
IRF
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1irf_EBI.jpg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
5533026
|
| http://dbpedia.org/ontology/wikiPageLength
|
9979
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1099033228
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/DNA_methylation +
, http://dbpedia.org/resource/Diabetes +
, http://dbpedia.org/resource/Autoimmune_disease +
, http://dbpedia.org/resource/Transcription_%28genetics%29 +
, http://dbpedia.org/resource/Germinal_center +
, http://dbpedia.org/resource/Innate_immune_system +
, http://dbpedia.org/resource/Common_myeloid_progenitor +
, http://dbpedia.org/resource/Carcinogenesis +
, http://dbpedia.org/resource/Natural_killer_cell +
, http://dbpedia.org/resource/Gene +
, http://dbpedia.org/resource/N-terminal +
, http://dbpedia.org/resource/IRF6 +
, http://dbpedia.org/resource/Cellular_differentiation +
, http://dbpedia.org/resource/Myeloid_tissue +
, http://dbpedia.org/resource/Ventricular_hypertrophy +
, http://dbpedia.org/resource/CD8A +
, http://dbpedia.org/resource/Kinase +
, http://dbpedia.org/resource/Secondary_structure +
, http://dbpedia.org/resource/Dendritic_cell +
, http://dbpedia.org/resource/IRF1 +
, http://dbpedia.org/resource/Phosphorylation +
, http://dbpedia.org/resource/Toll-like_receptor +
, http://dbpedia.org/resource/Atherosclerosis +
, http://dbpedia.org/resource/IRF4 +
, http://dbpedia.org/resource/Inflammatory_cytokine +
, http://dbpedia.org/resource/Conserved_sequence +
, http://dbpedia.org/resource/IRF7 +
, http://dbpedia.org/resource/Monocyte +
, http://dbpedia.org/resource/IRF9 +
, http://dbpedia.org/resource/Upstream_and_downstream_%28DNA%29 +
, http://dbpedia.org/resource/Common_lymphoid_progenitor +
, http://dbpedia.org/resource/Repressor +
, http://dbpedia.org/resource/IRF5 +
, http://dbpedia.org/resource/IRF8 +
, http://dbpedia.org/resource/Kaposi%27s_sarcoma-associated_herpesvirus +
, http://dbpedia.org/resource/Protein_folding +
, http://dbpedia.org/resource/B_cell +
, http://dbpedia.org/resource/Kaposi_sarcoma +
, http://dbpedia.org/resource/TANK-binding_kinase_1 +
, http://dbpedia.org/resource/CD4 +
, http://dbpedia.org/resource/Macrophage +
, http://dbpedia.org/resource/T_cell +
, http://dbpedia.org/resource/Interferon +
, http://dbpedia.org/resource/Regulation_of_gene_expression +
, http://dbpedia.org/resource/IRF3 +
, http://dbpedia.org/resource/Systemic_lupus_erythematosus +
, http://dbpedia.org/resource/Pattern_recognition_receptor +
, http://dbpedia.org/resource/Category:Transcription_factors +
, http://dbpedia.org/resource/Interferon_type_I +
, http://dbpedia.org/resource/Stroke +
, http://dbpedia.org/resource/Category:Protein_families +
, http://dbpedia.org/resource/Granulocyte +
, http://dbpedia.org/resource/Fatty_liver_disease +
, http://dbpedia.org/resource/IRF2 +
, http://dbpedia.org/resource/Amino_acids +
|
| http://dbpedia.org/property/caption
|
interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
|
| http://dbpedia.org/property/interpro
|
IPR001346
|
| http://dbpedia.org/property/name
|
Interferon regulatory factor transcription factor
|
| http://dbpedia.org/property/pfam
|
PF00605
|
| http://dbpedia.org/property/scop
|
1
|
| http://dbpedia.org/property/symbol
|
IRF
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:JAK-STAT_signaling_pathway +
, http://dbpedia.org/resource/Template:Commons_category-inline +
, http://dbpedia.org/resource/Template:InterPro_content +
, http://dbpedia.org/resource/Template:MeshName +
, http://dbpedia.org/resource/Template:Short_description +
, http://dbpedia.org/resource/Template:Transcription_factors +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Infobox_protein_family +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Transcription_factors +
, http://dbpedia.org/resource/Category:Protein_families +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Proteins +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Interferon_regulatory_factors?oldid=1099033228&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1irf_EBI.jpg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Interferon_regulatory_factors +
|
| owl:sameAs |
http://rdf.freebase.com/ns/m.02p9g7z +
, https://global.dbpedia.org/id/4npxP +
, http://dbpedia.org/resource/Interferon_regulatory_factors +
, http://www.wikidata.org/entity/Q6046461 +
, http://ru.dbpedia.org/resource/%D0%A0%D0%B5%D0%B3%D1%83%D0%BB%D1%8F%D1%82%D0%BE%D1%80%D0%BD%D1%8B%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D1%84%D0%B5%D1%80%D0%BE%D0%BD%D0%B0 +
|
| rdf:type |
http://dbpedia.org/class/yago/Group100031264 +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/class/yago/Organization108008335 +
, http://dbpedia.org/class/yago/YagoPermanentlyLocatedEntity +
, http://www.wikidata.org/entity/Q206229 +
, http://dbpedia.org/ontology/Biomolecule +
, http://dbpedia.org/class/yago/Unit108189659 +
, http://dbpedia.org/ontology/Protein +
, http://dbpedia.org/class/yago/SocialGroup107950920 +
, http://www.wikidata.org/entity/Q8054 +
, http://dbpedia.org/class/yago/Family108078020 +
, http://dbpedia.org/class/yago/YagoLegalActorGeo +
, http://dbpedia.org/class/yago/YagoLegalActor +
|
| rdfs:comment |
Interferon regulatory factors (IRF) are pr … Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. Some viruses have evolved defense mechanisms that regulate and interfere with IRF functions to escape the host immune system. For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 intrming oncoprotein that inhibits type 1 int
, Регуляторные факторы интерферонов — белки, … Регуляторные факторы интерферонов — белки, которые регулируют транскрипцию интерферонов. (см регуляцию экспрессии генов) Они используются в . Регуляторные факторы интерферона содержат консервативную область около 120 аминокислот, содержащиеся в , которая специфически связывается с последовательностью интерферонного консенсуса (ICS), нкаходящегосяся генами интерферона. Остальные части последовательности регуляторного фактора интерферона изменяются в зависимости от точной функции белка.тся в зависимости от точной функции белка.
|
| rdfs:label |
Interferon regulatory factors
, Регуляторные факторы интерферона
|
