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فريدريك إم ريتشاردز (بالإنجليزية: Frederic … فريدريك إم ريتشاردز (بالإنجليزية: Frederic M. Richards) هو أحيائي فيزيائي وكيميائي وعالم أحياء وعالم كيمياء حيوية أمريكي، ولد في 19 أغسطس 1925 في نيويورك في الولايات المتحدة، وتوفي في 11 يناير 2009 في غويلفورد في الولايات المتحدة. اشتهر ريتشاردز بحل التركيب البلوري لإنزيم الريبونوكلياز إس في عام 1967، وبتعريف مفهوم السطح النفوذ للمذيبات. ساهم ريتشاردز كذلك في العديد من النتائج التجريبية والنظرية الرئيسية وطور أساليب جديدة وحصل على أكثر من 20000 اقتباس في العديد من الدوريات البحثية. تضمنت تلك الاقتباسات البلورة البروتينية والكيمياء الحيوية للريبونوكلياز المنقسم ونفوذية المذيبات والتنظيم الداخلي للبروتينات ومكتبة أول روتامير جانبية السلسلة وعلم البلورات عالي الضغط وأنواع جديدة من العلامات الكيميائية مثل البيوتين/ الأفيدين والرنين المغناطيسي النووي (NMR) ومشعر الانزياح الكيميائي والتوصيف الهيكلي والفيزيائي الحيوي لآثار الطفرات. قضى ريتشاردز كامل حياته المهنية في البحث الأكاديمي في جامعة ييل حيث حصل على رتبة أستاذية ستيرلنغ للفيزياء الحيوية الجزيئية والكيمياء الحيوية في القسم الذي أنشأه وترأسه ليصبح «أحد المراكز الرئيسية في العالم لدراسة الفيزياء الحيوية والبيولوجيا الهيكلية». انتُخب ريتشاردز من قبل الأكاديمية الوطنية للعلوم بالولايات المتحدة الأمريكية والأكاديمية الأمريكية للفنون والعلوم وحصل على العديد من الجوائز العلمية الأخرى. شغل منصب رئيس صندوق جين كوفين تشايلدز التذكاري للبحوث الطبية وانتُخب رئيسًا لكل من الجمعية الأمريكية للكيمياء الحيوية والبيولوجيا الجزيئية (ASBMB) والمجتمع الفيزيائي الحيوي.لجزيئية (ASBMB) والمجتمع الفيزيائي الحيوي.
, Frederic Middlebrook Richards (August 19, … Frederic Middlebrook Richards (August 19, 1925 – January 11, 2009), commonly referred to as Fred Richards, was an American biochemist and biophysicist known for solving the pioneering crystal structure of the ribonuclease S enzyme in 1967 and for defining the concept of solvent-accessible surface. He contributed many key experimental and theoretical results and developed new methods, garnering over 20,000 journal citations in several quite distinct research areas. In addition to the protein crystallography and biochemistry of ribonuclease S, these included solvent accessibility and internal packing of proteins, the first side-chain rotamer library, high-pressure crystallography, new types of chemical tags such as biotin/avidin, the nuclear magnetic resonance (NMR) chemical shift index, and structural and biophysical characterization of the effects of mutations. Richards spent his entire academic research career at Yale University, where he became Sterling Professor of Molecular Biophysics and Biochemistry in the department that he created and chaired, "one of the major centers in the world for the study of biophysics and structural biology". He was elected to the National Academy of Sciences USA and the American Academy of Arts and Sciences, and received many other scientific awards. He served as head of the Jane Coffin Childs Memorial Fund for Medical Research and was elected as president both of the American Society for Biochemistry and Molecular Biology (ASBMB) and of the Biophysical Society.gy (ASBMB) and of the Biophysical Society.
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Solving the 3rd-ever crystal structure of a protein – ribonuclease S; defining solvent-accessible surface
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Studies on the density and composition of some protein crystals, including a preliminary investigation of the crystal structure of zinc diglycinate monohydrate
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Frederic Middlebrook Richards (August 19, … Frederic Middlebrook Richards (August 19, 1925 – January 11, 2009), commonly referred to as Fred Richards, was an American biochemist and biophysicist known for solving the pioneering crystal structure of the ribonuclease S enzyme in 1967 and for defining the concept of solvent-accessible surface. He contributed many key experimental and theoretical results and developed new methods, garnering over 20,000 journal citations in several quite distinct research areas. In addition to the protein crystallography and biochemistry of ribonuclease S, these included solvent accessibility and internal packing of proteins, the first side-chain rotamer library, high-pressure crystallography, new types of chemical tags such as biotin/avidin, the nuclear magnetic resonance (NMR) chemical shift index, and resonance (NMR) chemical shift index, and
, فريدريك إم ريتشاردز (بالإنجليزية: Frederic M. Richards) هو أحيائي فيزيائي وكيميائي وعالم أحياء وعالم كيمياء حيوية أمريكي، ولد في 19 أغسطس 1925 في نيويورك في الولايات المتحدة، وتوفي في 11 يناير 2009 في غويلفورد في الولايات المتحدة.
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Frederic M. Richards
, فريدريك إم ريتشاردز
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