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트립토판 트립토필퀴논(영어: tryptophan tryptophylquinone, TTQ)은 단백질 내에서 아미노산의 번역 후 변형에 의해 생성되는 효소 보조 인자이다. 인 메틸아민 탈수소효소는 촉매 기능을 위해 트립토판 트립토필퀴논을 필요로 한다.
, La triptòfan triptofilquinona (TTQ, per ab … La triptòfan triptofilquinona (TTQ, per abreujar) és un cofactor (que pot considerar-se un coenzim, pel fet de ser una molècula orgànica) que prové de la modificació post-traduccional de dos triptòfans residuals de la metilamina deshidrogenasa. La TTQ participa en la reacció de desaminació oxidativa de la metilamina (que esdevé formaldehid i amoníac) catalitzada per l'enzim MADH, del qual n’és l'apoenzim. Les primeres mencions del coenzim TTQ daten dels anys noranta. No obstant, no va ser fins a l'any 2008 que va convertir-se en el centre d'un estudi bioquímic. A partir d'aquí s'han realitzat nombroses investigacions per determinar-ne les característiques, sobretot relacionades amb la seva biosíntesi. Sobre aquest aspecte s'ha descobert que la biosíntesi de la triptòfan triptofilquinona està regulada per l'enzim . S'han definit nombroses mutacions en el gen que codifica per la MauG i impedeixen la síntesi de TTQ, cosa que impedeix el bon funcionament de la metilamina deshidrogenasa, tot i que no s'ha pogut relacionar amb cap patologia, ja que les proves han estat relacionades amb bacteris.roves han estat relacionades amb bacteris.
, Tryptophan tryptophylquinone (TTQ) is an enzyme cofactor, generated by posttranslational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function.
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Tryptophan tryptophylquinone (TTQ) is an enzyme cofactor, generated by posttranslational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function.
, La triptòfan triptofilquinona (TTQ, per ab … La triptòfan triptofilquinona (TTQ, per abreujar) és un cofactor (que pot considerar-se un coenzim, pel fet de ser una molècula orgànica) que prové de la modificació post-traduccional de dos triptòfans residuals de la metilamina deshidrogenasa. La TTQ participa en la reacció de desaminació oxidativa de la metilamina (que esdevé formaldehid i amoníac) catalitzada per l'enzim MADH, del qual n’és l'apoenzim.er l'enzim MADH, del qual n’és l'apoenzim.
, 트립토판 트립토필퀴논(영어: tryptophan tryptophylquinone, TTQ)은 단백질 내에서 아미노산의 번역 후 변형에 의해 생성되는 효소 보조 인자이다. 인 메틸아민 탈수소효소는 촉매 기능을 위해 트립토판 트립토필퀴논을 필요로 한다.
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TTQ
, 트립토판 트립토필퀴논
, Tryptophan tryptophylquinone
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