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Emtricitabina/rilpivirina/tenofovir alafen … Emtricitabina/rilpivirina/tenofovir alafenamida, comercializado sob a denominação de Odefsey, é um medicamento antivírico utilizado no tratamento de adultos e adolescentes (com 12 anos de idade ou mais e com um peso de, pelo menos, 35 kg) com infeção pelo vírus da imunodeficiência humana do tipo 1 (VIH-1), o vírus que causa a síndrome da imunodeficiência adquirida (SIDA). O Odefsey está disponível na forma de comprimidos, cada um contendo 200 mg de emtricitabina, 25 mg de rilpivirina e 25 mg de tenofovir alafenamida.pivirina e 25 mg de tenofovir alafenamida.
, Tenofovir alafenamide is een geneesmiddel … Tenofovir alafenamide is een geneesmiddel dat gebruikt wordt voor de behandeling van hiv (als onderdeel van HAART). Binnen de antiretrovirale middelen behoort Tenofovir tot de klasse van nucleotide-analoge reversetranscriptaseremmers. Tenofovir alafenamide is een prodrug van het eigenlijke Tenofovir, en wordt toegediend in de vorm van een fumaraat. Het middel wordt vaak ook kortweg TAF (van Tenofovir alafenamide fumaraat) genoemd. Tenofovir alafenamide is de tweede prodrug van Tenofovir, en is op de markt sinds eind 2015. De voorloper van TAF is Tenofovir disoproxil (TDF).per van TAF is Tenofovir disoproxil (TDF).
, 젠보야(Genvoya)는 후천성면역결핍증 치료제로, 테노포비르 알라페나미드 … 젠보야(Genvoya)는 후천성면역결핍증 치료제로, 테노포비르 알라페나미드 푸마르산염(Tenofovir Alafenamide Fumarate), 엘비테그라비르(Elvitegravir), 엠트리시타빈(Emtricitabine), 코비시스타트 이산화규소(Cobicistat Silicon Dioxide) 성분으로 구성되어 있다. 각 성분에 대해 내성 관련 치환이 없는 성인과 만 12세 이상 청소년이 복용할 수 있으며 하루 1정을 음식과 함께 복용하면 된다. 주요 성분인 테노포비르 알라페나미드(TAF)는 림프구 내로 흡수된 후에 그 효과가 발휘되는 표적 전구 약물(prodrug)로, 젠보야는 이를 통해 후천성면역결핍증의 원인 바이러스인 HIV에 대한 항바이러스 효과를 발휘한다. 젠보야는 이보다 앞서 출시되었던 후천성면역결핍증 치료제인 스트리빌드(Stribild)와의 비교 임상 실험에서 비열등한 지속적인 바이러스 억제 효과를 입증했다. 임상은 치료 경험이 없는 HIV-1 감염 성인 환자를 대상으로 진행되었으며, 48주 시점에 젠보야 복용 환자군의 92%, 스트리빌드 복용 환자군의 90%에서 바이러스 억제 효과가 나타났다. 국내에는 2017년 2월 급여 출시되어 2017년 6월 현재 국립중앙의료원, 서울순천향대병원, 연세대학교세브란스병원, 삼성서울병원, 분당서울대병원, 충남대병원 등 약 50곳의 주요 병원에서 처방받을 수 있다.분당서울대병원, 충남대병원 등 약 50곳의 주요 병원에서 처방받을 수 있다.
, تينوفوفير ألافيناميد (بالإنجليزية: Tenofovir alafenamide) هو دواء يُستعمل في علاج:
* التهاب الكبد ب
, Тенофовира алафенамид фумарат (МНН, ранее … Тенофовира алафенамид фумарат (МНН, ранее GS-7340) — нуклеотидный ингибитор обратной транскриптазы и пролекарство тенофовира. Он находится в стадии разработки компанией Gilead. Предназначен для лечения ВИЧ-инфекции и хронического гепатита В, применяется в виде Тенофовир алафенамид фумарат (ТАФ). Тесно связан с широко используемым ингибитором обратной транскриптазы Тенофовир дизопроксил, ТАФ обладает большей противовирусной активностью и лучше распределяется в лимфоидных тканях. лучше распределяется в лимфоидных тканях.
, 丙酚替诺福韦（Tenofovir alafenamide，缩写TAF，商品名韦立德（Vemlidy））是一种口服抗逆转录病毒药物，临床上应用其延胡索酸盐的形式（富马酸丙酚替诺福韦) 用于治疗乙型肝炎或与其他药物联用治疗艾滋病。 该药为替诺福韦的前药，由吉利德科学研发。与常用的逆转录酶抑制剂替诺福韦二吡呋酯（TDF）相比，丙酚替诺福韦具有更强的抗病毒活性和更好的淋巴组织分布。该药于2016年11月获得FDA批准上市。
, Tenofovir alafenamide, sold under the bran … Tenofovir alafenamide, sold under the brand name Vemlidy, is a hepatitis B virus (HBV) nucleotide reverse transcriptase inhibitor medication for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. It is taken by mouth. Tenofovir alafenamide is a prodrug of tenofovir. It was developed by Gilead Sciences based on the protide technology of Chris McGuigan for use in the treatment of HIV/AIDS and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (TDF), TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent. Vemlidy was approved by the U.S. Food and Drug Administration (FDA) in November 2016.rug Administration (FDA) in November 2016.
, テノホビル・アラフェナミド（英: Tenofovir alafenamide、INN/USAN、GS-7340）は、核酸逆転写酵素阻害剤であり、テノホビルのプロドラッグである。
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تينوفوفير ألافيناميد (بالإنجليزية: Tenofovir alafenamide) هو دواء يُستعمل في علاج:
* التهاب الكبد ب
, 丙酚替诺福韦（Tenofovir alafenamide，缩写TAF，商品名韦立德（Vemlidy））是一种口服抗逆转录病毒药物，临床上应用其延胡索酸盐的形式（富马酸丙酚替诺福韦) 用于治疗乙型肝炎或与其他药物联用治疗艾滋病。 该药为替诺福韦的前药，由吉利德科学研发。与常用的逆转录酶抑制剂替诺福韦二吡呋酯（TDF）相比，丙酚替诺福韦具有更强的抗病毒活性和更好的淋巴组织分布。该药于2016年11月获得FDA批准上市。
, Tenofovir alafenamide, sold under the bran … Tenofovir alafenamide, sold under the brand name Vemlidy, is a hepatitis B virus (HBV) nucleotide reverse transcriptase inhibitor medication for the treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease. It is taken by mouth.sated liver disease. It is taken by mouth.
, Tenofovir alafenamide is een geneesmiddel … Tenofovir alafenamide is een geneesmiddel dat gebruikt wordt voor de behandeling van hiv (als onderdeel van HAART). Binnen de antiretrovirale middelen behoort Tenofovir tot de klasse van nucleotide-analoge reversetranscriptaseremmers. Tenofovir alafenamide is een prodrug van het eigenlijke Tenofovir, en wordt toegediend in de vorm van een fumaraat. Het middel wordt vaak ook kortweg TAF (van Tenofovir alafenamide fumaraat) genoemd. Tenofovir alafenamide is de tweede prodrug van Tenofovir, en is op de markt sinds eind 2015. De voorloper van TAF is Tenofovir disoproxil (TDF).per van TAF is Tenofovir disoproxil (TDF).
, Emtricitabina/rilpivirina/tenofovir alafen … Emtricitabina/rilpivirina/tenofovir alafenamida, comercializado sob a denominação de Odefsey, é um medicamento antivírico utilizado no tratamento de adultos e adolescentes (com 12 anos de idade ou mais e com um peso de, pelo menos, 35 kg) com infeção pelo vírus da imunodeficiência humana do tipo 1 (VIH-1), o vírus que causa a síndrome da imunodeficiência adquirida (SIDA). O Odefsey está disponível na forma de comprimidos, cada um contendo 200 mg de emtricitabina, 25 mg de rilpivirina e 25 mg de tenofovir alafenamida.pivirina e 25 mg de tenofovir alafenamida.
, 젠보야(Genvoya)는 후천성면역결핍증 치료제로, 테노포비르 알라페나미드 … 젠보야(Genvoya)는 후천성면역결핍증 치료제로, 테노포비르 알라페나미드 푸마르산염(Tenofovir Alafenamide Fumarate), 엘비테그라비르(Elvitegravir), 엠트리시타빈(Emtricitabine), 코비시스타트 이산화규소(Cobicistat Silicon Dioxide) 성분으로 구성되어 있다. 각 성분에 대해 내성 관련 치환이 없는 성인과 만 12세 이상 청소년이 복용할 수 있으며 하루 1정을 음식과 함께 복용하면 된다. 주요 성분인 테노포비르 알라페나미드(TAF)는 림프구 내로 흡수된 후에 그 효과가 발휘되는 표적 전구 약물(prodrug)로, 젠보야는 이를 통해 후천성면역결핍증의 원인 바이러스인 HIV에 대한 항바이러스 효과를 발휘한다. 젠보야는 이보다 앞서 출시되었던 후천성면역결핍증 치료제인 스트리빌드(Stribild)와의 비교 임상 실험에서 비열등한 지속적인 바이러스 억제 효과를 입증했다. 임상은 치료 경험이 없는 HIV-1 감염 성인 환자를 대상으로 진행되었으며, 48주 시점에 젠보야 복용 환자군의 92%, 스트리빌드 복용 환자군의 90%에서 바이러스 억제 효과가 나타났다.92%, 스트리빌드 복용 환자군의 90%에서 바이러스 억제 효과가 나타났다.
, Тенофовира алафенамид фумарат (МНН, ранее … Тенофовира алафенамид фумарат (МНН, ранее GS-7340) — нуклеотидный ингибитор обратной транскриптазы и пролекарство тенофовира. Он находится в стадии разработки компанией Gilead. Предназначен для лечения ВИЧ-инфекции и хронического гепатита В, применяется в виде Тенофовир алафенамид фумарат (ТАФ). Тесно связан с широко используемым ингибитором обратной транскриптазы Тенофовир дизопроксил, ТАФ обладает большей противовирусной активностью и лучше распределяется в лимфоидных тканях. лучше распределяется в лимфоидных тканях.
, テノホビル・アラフェナミド（英: Tenofovir alafenamide、INN/USAN、GS-7340）は、核酸逆転写酵素阻害剤であり、テノホビルのプロドラッグである。
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| rdfs:label |
Tenofovir alafenamide
, 테노포비르 알라페나미드
, Тенофовир алафенамид
, テノホビル アラフェナミド
, 丙酚替诺福韦
, Emtricitabina/rilpivirina/tenofovir alafenamida
, تينوفوفير ألافيناميد
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