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Sperm-mediated gene transfer (SMGT) is a t … Sperm-mediated gene transfer (SMGT) is a transgenic technique that transfers genes based on the ability of sperm cells to spontaneously bind to and internalize exogenous DNA and transport it into an oocyte during fertilization to produce genetically modified animals.1 Exogenous DNA refers to DNA that originates outside of the organism. Transgenic animals have been obtained using SMGT, but the efficiency of this technique is low. Low efficiency is mainly due to low uptake of exogenous DNA by the spermatozoa, reducing the chances of fertilizing the oocytes with transfected spermatozoa.2 In order to successfully produce transgenic animals by SMGT, the spermatozoa must attach the exogenous DNA into the head and these transfected spermatozoa must maintain their functionality to fertilize the oocyte.2 Genetically modified animals produced by SMGT are useful for research in biomedical, agricultural, and veterinary fields of study. SMGT could also be useful in generating animals as models for human diseases or lead to future discoveries relating to human gene therapy.iscoveries relating to human gene therapy.
, Der spermienvermittelte Gentransfer (engl. … Der spermienvermittelte Gentransfer (engl. sperm-mediated gene transfer, SMGT) ist ein Verfahren zur Gentherapie, welches Spermien als Vektor verwendet, um einen transgenen Organismus zu erzeugen. Der spermienvermittelte Gentransfer kombiniert die künstliche Befruchtung durch eine intrazytoplasmatische Spermieninjektion (ICSI) mit DNA-beladenen Spermien.jektion (ICSI) mit DNA-beladenen Spermien.
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Sperm-mediated gene transfer (SMGT) is a t … Sperm-mediated gene transfer (SMGT) is a transgenic technique that transfers genes based on the ability of sperm cells to spontaneously bind to and internalize exogenous DNA and transport it into an oocyte during fertilization to produce genetically modified animals.1 Exogenous DNA refers to DNA that originates outside of the organism. Transgenic animals have been obtained using SMGT, but the efficiency of this technique is low. Low efficiency is mainly due to low uptake of exogenous DNA by the spermatozoa, reducing the chances of fertilizing the oocytes with transfected spermatozoa.2 In order to successfully produce transgenic animals by SMGT, the spermatozoa must attach the exogenous DNA into the head and these transfected spermatozoa must maintain their functionality to fertilize the ooin their functionality to fertilize the oo
, Der spermienvermittelte Gentransfer (engl. … Der spermienvermittelte Gentransfer (engl. sperm-mediated gene transfer, SMGT) ist ein Verfahren zur Gentherapie, welches Spermien als Vektor verwendet, um einen transgenen Organismus zu erzeugen. Der spermienvermittelte Gentransfer kombiniert die künstliche Befruchtung durch eine intrazytoplasmatische Spermieninjektion (ICSI) mit DNA-beladenen Spermien.jektion (ICSI) mit DNA-beladenen Spermien.
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Spermienvermittelter Gentransfer
, Sperm-mediated gene transfer
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