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Butirato de sódio é o composto orgânico de … Butirato de sódio é o composto orgânico de fórmula Na(C3H7COO), o sal de sódio do ácido butírico. Ele tem vários efeitos na cultura de células de mamíferos inclusive a inibição da proliferação, indução da diferenciação celular e a indução ou repressão da expressão genética. Neste caso, o composto pode ser usado no laboratório para causar estes efeitos. Especificamente, o tratamento das células com butirato resulta na hiperacetilação da histona, e o butirato inibe a atividade da histona deacetilase. Butirato tem sido um veículo essencial para determinar o papel da na estrutura e função da cromatina. A inibição da atividade do afeta a expressão de apenas 2% dos genes dos mamíferos.ssão de apenas 2% dos genes dos mamíferos.
, Natria buterato aŭ butanato de natrio, est … Natria buterato aŭ butanato de natrio, estas natria kombinaĵo el buterata acido. Ĝi uzatas en laboratorio kiel agento pri modifigo de la kromatina strukturo, plibonigas la efikecon de la transfekcio kaj la ĉelan vivon. Ĝi plenumas plurajn efektojn en la kulturo de mamĉeloj inkluzive de inhibado de dismultiĝo, induktado de diferencigo kaj induktiva aŭ reprimiva efekto de genetika esprimo. Pro tio, ĝi uzatas en laboratorio por plenumado de unu el tiuj efektoj. Natria buterato uzatas en medicino kiel nutraĵo por la intestaj ĉeloj, kiu akceligas la regeneradon de la intesta mukozo kaj inhibas la kreskon da la kancerĉeloj. Specife, buterata traktado de la ĉeloj rezultas en hiperacetiligo de histono, kaj la buterato siavice inhibas la aktivecon de la histona malacetilazo. Buterato elmontriĝis esenca vehiklo por determinado de la rolo de la histona acetiligo en kromatina strukturo kaj funkcio. Oni kredas ke la inhibado de la aktiveco pri la histona malacetilazo kompromitas nur 2% de la genoj de la mamuloj. Studoj elmontras ke la butanato de natrio estas potence utila en la traktado de spina muskola atrofio.a en la traktado de spina muskola atrofio.
, Natriumbutyrat ist ein weißes hygroskopisches Natriumsalz der Buttersäure. Es hat einen unangenehmen Geruch und ist stabil gegenüber Licht und Hitze.
, Sodium butyrate is a compound with formula … Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes. In the lab, sodium butyrate is usually found as a white, water-soluble, crystalline solid. The chemical is notable for having a very strong, unpleasant smell that lingers. When working with sodium butyrate, gloves, eye protection and respiratory masks are advised for safety purposes. The compound is found in human diet, notably produced in large amounts from dietary fiber in the gut and present in Parmesan cheese and butter. Nevertheless, the most common source of sodium butyrate in the gut is from consumption of legumes.in the gut is from consumption of legumes.
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| rdfs:comment |
Butirato de sódio é o composto orgânico de … Butirato de sódio é o composto orgânico de fórmula Na(C3H7COO), o sal de sódio do ácido butírico. Ele tem vários efeitos na cultura de células de mamíferos inclusive a inibição da proliferação, indução da diferenciação celular e a indução ou repressão da expressão genética. Neste caso, o composto pode ser usado no laboratório para causar estes efeitos. Especificamente, o tratamento das células com butirato resulta na hiperacetilação da histona, e o butirato inibe a atividade da histona deacetilase. Butirato tem sido um veículo essencial para determinar o papel da na estrutura e função da cromatina. A inibição da atividade do afeta a expressão de apenas 2% dos genes dos mamíferos.ssão de apenas 2% dos genes dos mamíferos.
, Natriumbutyrat ist ein weißes hygroskopisches Natriumsalz der Buttersäure. Es hat einen unangenehmen Geruch und ist stabil gegenüber Licht und Hitze.
, Sodium butyrate is a compound with formula … Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expression. As such, it can be used in lab to bring about any of these effects. Specifically, butyrate treatment of cells results in histone hyperacetylation, and butyrate itself inhibits class I histone deacetylase (HDAC) activity, specifically HDAC1, HDAC2, HDAC3, and butyrate can be used in determining histone deacetylene in chromatin structure and function. Inhibition of HDAC activity is estimated to affect the expression of only 2% of mammalian genes. expression of only 2% of mammalian genes.
, Natria buterato aŭ butanato de natrio, est … Natria buterato aŭ butanato de natrio, estas natria kombinaĵo el buterata acido. Ĝi uzatas en laboratorio kiel agento pri modifigo de la kromatina strukturo, plibonigas la efikecon de la transfekcio kaj la ĉelan vivon. Ĝi plenumas plurajn efektojn en la kulturo de mamĉeloj inkluzive de inhibado de dismultiĝo, induktado de diferencigo kaj induktiva aŭ reprimiva efekto de genetika esprimo. Pro tio, ĝi uzatas en laboratorio por plenumado de unu el tiuj efektoj.orio por plenumado de unu el tiuj efektoj.
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| rdfs:label |
Natriumbutyrat
, Natria buterato
, Butirato de sódio
, Sodium butyrate
|
