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La méthionine adénosyltransférase (MAT), o … La méthionine adénosyltransférase (MAT), ou S-adénosylméthionine synthétase, est une transférase qui catalyse la réaction : ATP + L-méthionine + H2O phosphate + pyrophosphate + S-adénosyl-L-méthionine. Cette enzyme, anciennement classée EC 2.4.2.13, réalise la biosynthèse de la S-adénosylméthionine à partir d'ATP et de méthionine, un acide aminé soufré apolaire. Cette activité enzymatique est portée par une grande variété de protéines : la plupart des méthionine adénosyltransférases sont des homo-oligomères et le plus grand nombre sont des tétramères. Les monomères sont constitués de trois domaines formés par des séquences peptidiques non consécutives et les sous-unités interagissent à travers de grandes surfaces plates hydrophobes pour former les dimères.lates hydrophobes pour former les dimères.
, S-Adenosylmethionine synthetase (EC 2.5.1. … S-Adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).d) and ATP (the basic currency of energy).
, La metionina adenosiltransferasa (MAT) en … La metionina adenosiltransferasa (MAT) en una enzima que en conjunto con el ATP cataliza la formación S-Adenosilmetionina (SAM) a partir de adenosina trifosfato (ATP) y el aminoácido metionina. Durante esta reacción, se consume una molécula de ATP, metionina y agua y se genera un grupo fosfato libre, un difosfato y la S – Adenosil Metionina. La principal función de la S-Adenosil metionina es transferir o donar grupos metilo para cumplir diferentes reacciones bioquímicas tales como la transmetilación, y . Una de las funciones específicas de la SAM es la biosíntesis de poliaminas. La Metionina adenosiltransferasa está codificada por dos genes, el gen MAT1A y el gen MAT2A. Es importante recalcar que el gen MAT1A se expresa principalmente en el hígado mientras que el MAT2A tiene un patrón de expresión disperso en todo el organismo.e expresión disperso en todo el organismo.
, 甲硫氨酸腺苷转移酶（英語：Methionine adenosyltransferase）是一种催化甲硫氨酸与ATP合成S-腺苷甲硫氨酸（SAM）的酶。
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Methionine adenosyltransferase in a complex ADP and l-methionine.
, S-adenosylmethionine synthetase with ADP
, S-adenosylmethionine synthase 2, tetramer, Human
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甲硫氨酸腺苷转移酶（英語：Methionine adenosyltransferase）是一种催化甲硫氨酸与ATP合成S-腺苷甲硫氨酸（SAM）的酶。
, La metionina adenosiltransferasa (MAT) en … La metionina adenosiltransferasa (MAT) en una enzima que en conjunto con el ATP cataliza la formación S-Adenosilmetionina (SAM) a partir de adenosina trifosfato (ATP) y el aminoácido metionina. Durante esta reacción, se consume una molécula de ATP, metionina y agua y se genera un grupo fosfato libre, un difosfato y la S – Adenosil Metionina.un difosfato y la S – Adenosil Metionina.
, La méthionine adénosyltransférase (MAT), ou S-adénosylméthionine synthétase, est une transférase qui catalyse la réaction : ATP + L-méthionine + H2O phosphate + pyrophosphate + S-adénosyl-L-méthionine.
, S-Adenosylmethionine synthetase (EC 2.5.1. … S-Adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase (MAT), is an enzyme that creates S-adenosylmethionine (also known as AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).d) and ATP (the basic currency of energy).
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S-Adenosylmethionine synthetase enzyme
, Méthionine adénosyltransférase
, 甲硫氨酸腺苷转移酶
, Metionina adenosiltransferasa
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