| http://dbpedia.org/ontology/abstract
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Rhynchophyllina es un alcaloide que se enc … Rhynchophyllina es un alcaloide que se encuentra en ciertas especies de Uncaria(Rubiaceae), especialmente Uncaria rhynchophylla y Uncaria tomentosa. Es un no competitivo (IC50 = 43.2 microM) y bloqueador del canal de calcio. También se produce de forma natural en las hojas de Mitragyna speciosa (también una Rubiaceae), nativa de Tailandia.bién una Rubiaceae), nativa de Tailandia.
, Rhynchophylline is an alkaloid found in ce … Rhynchophylline is an alkaloid found in certain Uncaria species (Rubiaceae), notably Uncaria rhynchophylla and Uncaria tomentosa. It also occurs in the leaves of Mitragyna speciosa (kratom), a tree native to Thailand. Chemically, it is related to the alkaloid mitragynine. Rhynchophylline is a non-competitive NMDA antagonist (IC50 = 43.2 μM) and a calcium channel blocker. Uncaria species have had a variety of uses in traditional herbal medicine, such as for lightheadedness, convulsions, numbness, and hypertension. These uses have been associated with the presence of rhynchophylline and have encouraged its investigation as a drug candidate for several cardiovascular and central nervous system diseases; however, few clinically relevant studies have been conducted.ally relevant studies have been conducted.
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| http://dbpedia.org/ontology/alternativeName
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Rhynchophyllin
, Rhyncophylline
, Mitrinermin
, Mitrinermine
, Rhynocophylline
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| http://dbpedia.org/ontology/iupacName
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Methyl (2E)-2-[(1′R,6′R,7′S,8a′S)-6′-ethyl-2-oxo-1,2,2′,3′,6′,7′,8′,8a′-octahydro-5′H-spiro[indole-3,1′-indolizin]-7′-yl]-3-methoxyprop-2-enoate
, Methyl (7β,16E,20α)-16-(methoxymethylene)-2-oxocorynoxan-17-oate
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18587740
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4924
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1083018305
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Chemical structure of rhynchophylline
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200
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Methyl -16--2-oxocorynoxan-17-oate
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| http://dbpedia.org/property/othernames
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Rhynocophylline
, Mitrinermin
, Rhynchophyllin
, Rhyncophylline
, Mitrinermine
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| http://dbpedia.org/property/pin
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Methyl -2-[-6′-ethyl-2-oxo-1,2,2′,3′,6′,7′,8′,8a′-octahydro-5′H-spiro[indole-3,1′-indolizin]-7′-yl]-3-methoxyprop-2-enoate
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changed
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changed
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| rdfs:comment |
Rhynchophylline is an alkaloid found in ce … Rhynchophylline is an alkaloid found in certain Uncaria species (Rubiaceae), notably Uncaria rhynchophylla and Uncaria tomentosa. It also occurs in the leaves of Mitragyna speciosa (kratom), a tree native to Thailand. Chemically, it is related to the alkaloid mitragynine. Rhynchophylline is a non-competitive NMDA antagonist (IC50 = 43.2 μM) and a calcium channel blocker. = 43.2 μM) and a calcium channel blocker.
, Rhynchophyllina es un alcaloide que se enc … Rhynchophyllina es un alcaloide que se encuentra en ciertas especies de Uncaria(Rubiaceae), especialmente Uncaria rhynchophylla y Uncaria tomentosa. Es un no competitivo (IC50 = 43.2 microM) y bloqueador del canal de calcio. También se produce de forma natural en las hojas de Mitragyna speciosa (también una Rubiaceae), nativa de Tailandia.bién una Rubiaceae), nativa de Tailandia.
|
| rdfs:label |
Rhynchophylline
, Rhynchophyllina
|
