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ロドデノール（Rhododenol）は白樺の樹皮やメグスリノキなどに多く含まれる成分。正確にはロドデンドロール(rhododendrol)。ラズベリーケトンのケトン基を水酸基に還元した形の化合物である。別名は、4-(4-ヒドロキシフェニル)-2-ブタノール (略称4-HPB)。 2008年にカネボウ化粧品が認可を得て医薬部外品の美白成分として化粧品に配合され、後に白斑の症状の訴えがあり2013年に回収された。症状の訴えは約2万人に上った。
, Rhododendrol (RD) also called 4-[(3R)-3-hy … Rhododendrol (RD) also called 4-[(3R)-3-hydroxybutyl]phenol (systemic name), is an organic compound with the formula C10H14O2. It is a naturally occurring ingredient present in many plants, such as the Rhododendron. The phenolic compound was first developed in 2010 as a tyrosinase inhibitor for skin-lightening cosmetics. In 2013, after rhododendrol reportedly caused skin depigmentation in consumers using RD-containing skin-brightening cosmetics, the cosmetics were withdrawn from the market. The skin condition, caused by RD, is called RD-induced leukoderma. Rhododendrol exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. It has been shown to impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. It is now well established that rhododendrol is a potent tyrosinase inhibitor.odendrol is a potent tyrosinase inhibitor.
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Rhododenol, RD, 4-(4-hydroxyphenyl)-2-butanol, (-)-Betuligenol, (R)-Frambinol, 4-Hydroxy-α-methyl-benzenepropanol
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4-[(3R)-3-hydroxybutyl]phenol
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4
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Rhododenol, RD, 4--2-butanol, -Betuligenol, -Frambinol, 4-Hydroxy-α-methyl-benzenepropanol
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| rdfs:comment |
ロドデノール（Rhododenol）は白樺の樹皮やメグスリノキなどに多く含まれる成分。正確にはロドデンドロール(rhododendrol)。ラズベリーケトンのケトン基を水酸基に還元した形の化合物である。別名は、4-(4-ヒドロキシフェニル)-2-ブタノール (略称4-HPB)。 2008年にカネボウ化粧品が認可を得て医薬部外品の美白成分として化粧品に配合され、後に白斑の症状の訴えがあり2013年に回収された。症状の訴えは約2万人に上った。
, Rhododendrol (RD) also called 4-[(3R)-3-hy … Rhododendrol (RD) also called 4-[(3R)-3-hydroxybutyl]phenol (systemic name), is an organic compound with the formula C10H14O2. It is a naturally occurring ingredient present in many plants, such as the Rhododendron. The phenolic compound was first developed in 2010 as a tyrosinase inhibitor for skin-lightening cosmetics. In 2013, after rhododendrol reportedly caused skin depigmentation in consumers using RD-containing skin-brightening cosmetics, the cosmetics were withdrawn from the market. The skin condition, caused by RD, is called RD-induced leukoderma. Rhododendrol exerts melanocyte cytotoxicity via a tyrosinase-dependent mechanism. It has been shown to impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. It is now well establisivation of GADD45. It is now well establis
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| rdfs:label |
ロドデノール
, Rhododendrol
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