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工艺化学是开发与优化合成方案和工业生产流程的药物化学分支，用于制造药物开发阶段所需要 … 工艺化学是开发与优化合成方案和工业生产流程的药物化学分支，用于制造药物开发阶段所需要的化合物。其研究重点与主要负责在药物研究早期阶段中设计并较小规模地合成分子的药物化学有所区别。 一般来说，药物化学家主要专注于利用便于调节的化学构件中快速合成大量化合物（通常用于SAR研究）。而药物发现化学中使用的反应库一般较小（例如，Buchwald-Hartwig 胺化、Suzuki 偶联和还原胺化等常见的反应）。 工艺化学家的任务则是确定一种安全、成本低、劳动效率高、符合绿色化学理念、可重复性强，并综合其他因素优化充分设计的化学工艺。通常，在寻找最短、最有效的合成路线时，工艺化学家必须设计创造性的合成解决方案，以减少高成本的官能团操作和氧化还原步骤。 本文只关注与小分子药物生产相关的化学和制造过程。生物医疗产品（通常称为“生物制剂”）的制造过程超出了本文的讨论范围。此外，与化工（例如传热和反应器设计）和药物配方相关的许多复杂因素在本文中仅作粗略介绍。外，与化工（例如传热和反应器设计）和药物配方相关的许多复杂因素在本文中仅作粗略介绍。
, Process chemistry is the arm of pharmaceut … Process chemistry is the arm of pharmaceutical chemistry concerned with the development and optimization of a synthetic scheme and pilot plant procedure to manufacture compounds for the drug development phase. Process chemistry is distinguished from medicinal chemistry, which is the arm of pharmaceutical chemistry tasked with designing and synthesizing molecules on small scale in the early drug discovery phase. Medicinal chemists are largely concerned with synthesizing a large number of compounds as quickly as possible from easily tunable chemical building blocks (usually for SAR studies). In general, the repertoire of reactions utilized in discovery chemistry is somewhat narrow (for example, the Buchwald-Hartwig amination, Suzuki coupling and reductive amination are commonplace reactions). In contrast, process chemists are tasked with identifying a chemical process that is safe, cost and labor efficient, “green,” and reproducible, among other considerations. Oftentimes, in searching for the shortest, most efficient synthetic route, process chemists must devise creative synthetic solutions that eliminate costly functional group manipulations and oxidation/reduction steps. This article focuses exclusively on the chemical and manufacturing processes associated with the production of small molecule drugs. Biological medical products (more commonly called “biologics”) represent a growing proportion of approved therapies, but the manufacturing processes of these products are beyond the scope of this article. Additionally, the many complex factors associated with chemical plant engineering (for example, heat transfer and reactor design) and drug formulation will be treated cursorily.rug formulation will be treated cursorily.
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工艺化学是开发与优化合成方案和工业生产流程的药物化学分支，用于制造药物开发阶段所需要 … 工艺化学是开发与优化合成方案和工业生产流程的药物化学分支，用于制造药物开发阶段所需要的化合物。其研究重点与主要负责在药物研究早期阶段中设计并较小规模地合成分子的药物化学有所区别。 一般来说，药物化学家主要专注于利用便于调节的化学构件中快速合成大量化合物（通常用于SAR研究）。而药物发现化学中使用的反应库一般较小（例如，Buchwald-Hartwig 胺化、Suzuki 偶联和还原胺化等常见的反应）。 工艺化学家的任务则是确定一种安全、成本低、劳动效率高、符合绿色化学理念、可重复性强，并综合其他因素优化充分设计的化学工艺。通常，在寻找最短、最有效的合成路线时，工艺化学家必须设计创造性的合成解决方案，以减少高成本的官能团操作和氧化还原步骤。 本文只关注与小分子药物生产相关的化学和制造过程。生物医疗产品（通常称为“生物制剂”）的制造过程超出了本文的讨论范围。此外，与化工（例如传热和反应器设计）和药物配方相关的许多复杂因素在本文中仅作粗略介绍。外，与化工（例如传热和反应器设计）和药物配方相关的许多复杂因素在本文中仅作粗略介绍。
, Process chemistry is the arm of pharmaceut … Process chemistry is the arm of pharmaceutical chemistry concerned with the development and optimization of a synthetic scheme and pilot plant procedure to manufacture compounds for the drug development phase. Process chemistry is distinguished from medicinal chemistry, which is the arm of pharmaceutical chemistry tasked with designing and synthesizing molecules on small scale in the early drug discovery phase.l scale in the early drug discovery phase.
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, 工艺化学
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