| http://dbpedia.org/ontology/abstract
|
Fosfotyrosinbindande domäner är proteinsek … Fosfotyrosinbindande domäner är proteinsekvenser som möjliggör inbindning till fosforylerade tyrosinrester samt N-terminala aminosyror. Det är en form av domän som uttrycks bland annat på proteiner i signaltransduktionskedjor av olika slag, och behövs för att binda samman olika proteiner och enzymer. binda samman olika proteiner och enzymer.
, In molecular biology, Phosphotyrosine-bind … In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif. The phosphotyrosine-binding domain of insulin receptor substrate-1 is not related to the phosphotyrosine-binding domain of tensin.Insulin receptor substrate-1 proteins contain both a pleckstrin homology domain and a phosphotyrosine binding (PTB) domain. The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus. Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac-LYASSNPApY-NH2 peptide in the juxtamembrane region of the insulin receptor. Further interactions via "bridged" water molecules are coordinated by residues an Asn and a Ser residue. The PTB domain has a compact, 7-stranded beta-sandwich structure, capped by a C-terminal helix. The substrate peptide fits into an L-shaped surface cleft formed from the C-terminal helix and strands 5 and 6. the C-terminal helix and strands 5 and 6.
|
| http://dbpedia.org/ontology/symbol
|
IRS
, PTB
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1wvh_EBI.jpg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
24010095
|
| http://dbpedia.org/ontology/wikiPageLength
|
4974
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1082979447
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/TLN2 +
, http://dbpedia.org/resource/Insulin_receptor_substrate_1 +
, http://dbpedia.org/resource/Protein_domains +
, http://dbpedia.org/resource/N_terminus +
, http://dbpedia.org/resource/Water_molecule +
, http://dbpedia.org/resource/TNS4 +
, http://dbpedia.org/resource/NOS1AP +
, http://dbpedia.org/resource/DOK4 +
, http://dbpedia.org/resource/DOK5 +
, http://dbpedia.org/resource/Alpha_helix +
, http://dbpedia.org/resource/DOK2 +
, http://dbpedia.org/resource/DOK3 +
, http://dbpedia.org/resource/Insulin_receptor +
, http://dbpedia.org/resource/Amino_terminus +
, http://dbpedia.org/resource/Arginine +
, http://dbpedia.org/resource/TLN1 +
, http://dbpedia.org/resource/Actin +
, http://dbpedia.org/resource/Focal_adhesion +
, http://dbpedia.org/resource/Peptide +
, http://dbpedia.org/resource/FRS2 +
, http://dbpedia.org/resource/FRS3 +
, http://dbpedia.org/resource/TNS_%28protein%29 +
, http://dbpedia.org/resource/Tensin +
, http://dbpedia.org/resource/APBA3 +
, http://dbpedia.org/resource/IRS2 +
, http://dbpedia.org/resource/Integrin +
, http://dbpedia.org/resource/Docking_protein_6 +
, http://dbpedia.org/resource/APBA1 +
, http://dbpedia.org/resource/APBA2 +
, http://dbpedia.org/resource/PTEN_%28gene%29 +
, http://dbpedia.org/resource/Category:Protein_domains +
, http://dbpedia.org/resource/Acetylation +
, http://dbpedia.org/resource/C-terminus +
, http://dbpedia.org/resource/Dok-7 +
, http://dbpedia.org/resource/Phosphotyrosine +
, http://dbpedia.org/resource/DOK1 +
, http://dbpedia.org/resource/Category:Membrane_proteins +
, http://dbpedia.org/resource/Protein_domain +
, http://dbpedia.org/resource/IRS1 +
, http://dbpedia.org/resource/Hydrogen_bonding +
, http://dbpedia.org/resource/Protein +
, http://dbpedia.org/resource/EPS8L2 +
, http://dbpedia.org/resource/EPS8L3 +
, http://dbpedia.org/resource/EPS8L1 +
, http://dbpedia.org/resource/TENC1 +
, http://dbpedia.org/resource/Beta-sandwich +
, http://dbpedia.org/resource/TNS1 +
, http://dbpedia.org/resource/SH2_domain +
, http://dbpedia.org/resource/Cytoplasmic +
, http://dbpedia.org/resource/Residue_%28chemistry%29 +
, http://dbpedia.org/resource/Tumor_suppressor_gene +
, http://dbpedia.org/resource/Category:Protein_families +
, http://dbpedia.org/resource/Tyrosine +
, http://dbpedia.org/resource/Actin_filaments +
, http://dbpedia.org/resource/Human +
, http://dbpedia.org/resource/Phosphorylated +
, http://dbpedia.org/resource/IRS4 +
, http://dbpedia.org/resource/Protein_interaction +
, http://dbpedia.org/resource/Pleckstrin_homology_domain +
, http://dbpedia.org/resource/EPS8 +
, http://dbpedia.org/resource/APPL1 +
, http://dbpedia.org/resource/TNS3 +
|
| http://dbpedia.org/property/caption
|
irs-1 ptb domain complexed with a il-4 receptor phosphopeptide, nmr, minimized average structure
, Structure of the PTB domain of tensin1.
|
| http://dbpedia.org/property/cdd
|
cd00934
, cd01204
|
| http://dbpedia.org/property/interpro
|
IPR013625
, IPR002404
|
| http://dbpedia.org/property/name
|
PTB domain
, Phosphotyrosine-binding domain
|
| http://dbpedia.org/property/pdb
|
A:1607-1738
|
| http://dbpedia.org/property/pfam
|
PF02174
, PF08416
|
| http://dbpedia.org/property/scop
|
1
|
| http://dbpedia.org/property/smart
|
PTBI
|
| http://dbpedia.org/property/symbol
|
PTB
, IRS
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Protein_domains +
, http://dbpedia.org/resource/Template:Short_description +
, http://dbpedia.org/resource/Template:Membrane-protein-stub +
, http://dbpedia.org/resource/Template:ELM +
, http://dbpedia.org/resource/Template:Pfam_box +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:PDB3 +
, http://dbpedia.org/resource/Template:Pfam +
, http://dbpedia.org/resource/Template:InterPro_content +
, http://dbpedia.org/resource/Template:Infobox_protein_family +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Protein_families +
, http://dbpedia.org/resource/Category:Membrane_proteins +
, http://dbpedia.org/resource/Category:Protein_domains +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Domains +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Phosphotyrosine-binding_domain?oldid=1082979447&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1wvh_EBI.jpg +
, http://commons.wikimedia.org/wiki/Special:FilePath/PDB_1irs_EBI.jpg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Phosphotyrosine-binding_domain +
|
| owl:sameAs |
http://sv.dbpedia.org/resource/Fosfotyrosinbindande_dom%C3%A4n +
, http://rdf.freebase.com/ns/m.07kb22p +
, https://global.dbpedia.org/id/4tPE4 +
, http://yago-knowledge.org/resource/Phosphotyrosine-binding_domain +
, http://www.wikidata.org/entity/Q7187588 +
, http://dbpedia.org/resource/Phosphotyrosine-binding_domain +
|
| rdf:type |
http://dbpedia.org/ontology/Biomolecule +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/class/yago/Group100031264 +
, http://www.wikidata.org/entity/Q206229 +
, http://dbpedia.org/class/yago/Organization108008335 +
, http://www.wikidata.org/entity/Q8054 +
, http://dbpedia.org/class/yago/SocialGroup107950920 +
, http://dbpedia.org/class/yago/Unit108189659 +
, http://dbpedia.org/class/yago/WikicatProteinFamilies +
, http://dbpedia.org/ontology/Protein +
, http://dbpedia.org/class/yago/YagoLegalActorGeo +
, http://dbpedia.org/class/yago/YagoLegalActor +
, http://dbpedia.org/class/yago/Family108078020 +
, http://dbpedia.org/class/yago/YagoPermanentlyLocatedEntity +
|
| rdfs:comment |
In molecular biology, Phosphotyrosine-bind … In molecular biology, Phosphotyrosine-binding domains are protein domains which bind to phosphotyrosine. The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (Pfam PF00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.beta integrin by binding to an NPXY motif.
, Fosfotyrosinbindande domäner är proteinsek … Fosfotyrosinbindande domäner är proteinsekvenser som möjliggör inbindning till fosforylerade tyrosinrester samt N-terminala aminosyror. Det är en form av domän som uttrycks bland annat på proteiner i signaltransduktionskedjor av olika slag, och behövs för att binda samman olika proteiner och enzymer. binda samman olika proteiner och enzymer.
|
| rdfs:label |
Phosphotyrosine-binding domain
, Fosfotyrosinbindande domän
|
