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A paxilina (em inglês paxilline) é um alca … A paxilina (em inglês paxilline) é um alcaloide indólico diterpénico tóxico tremorgénico que actua como.bloqueador dos canais de potássio. O organismo que produz esta micotoxina e do qual deriva o nome do composto é o fungo Penicillium paxilli. Um grupo de 17 de genes (cluster Pax) localizado no cromossoma Va desta espécie codifica as enzimas responsáveis pela síntese de paxilina. A paxilina é muito tóxica se ingerida, inalada ou absorvida pela pele, podendo danificar os olhos e actua como uma potente neurotoxina.lhos e actua como uma potente neurotoxina.
, La paxilline (en anglais paxilline) est une mycotoxine à effets trémorgéniques produite par . Elle agit en bloquant les canaux potassiques.
, Paxilline is a toxic, diterpene indole pol … Paxilline is a toxic, diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli which was first characterized in 1975. Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, and is potentially genotoxic. Paxilline was found to significantly extend the lifespan, healthspan, and mobility of aged C. elegans worms, but had no such effect on young worms. Paxilline was not found to induce seizures when injected intracerebroventricularly in mice but paradoxically had anticonvulsant activity against picrotoxin and pentylenetetrazol seizures in mice. It has also been used in mice to induce autism-like behaviors through inhibition of the BK channel.iors through inhibition of the BK channel.
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(2R,4bS,6aS,12bS,12cR,14aS)-4b-Hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-[1]benzopyrano[5′,6′:6,7]indeno[1,2-b]indol-3(4bH)-one
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| rdfs:comment |
A paxilina (em inglês paxilline) é um alca … A paxilina (em inglês paxilline) é um alcaloide indólico diterpénico tóxico tremorgénico que actua como.bloqueador dos canais de potássio. O organismo que produz esta micotoxina e do qual deriva o nome do composto é o fungo Penicillium paxilli. Um grupo de 17 de genes (cluster Pax) localizado no cromossoma Va desta espécie codifica as enzimas responsáveis pela síntese de paxilina. A paxilina é muito tóxica se ingerida, inalada ou absorvida pela pele, podendo danificar os olhos e actua como uma potente neurotoxina.lhos e actua como uma potente neurotoxina.
, La paxilline (en anglais paxilline) est une mycotoxine à effets trémorgéniques produite par . Elle agit en bloquant les canaux potassiques.
, Paxilline is a toxic, diterpene indole pol … Paxilline is a toxic, diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli which was first characterized in 1975. Paxilline is one of a class of tremorigenic mycotoxins, is a potassium channel blocker, and is potentially genotoxic.nel blocker, and is potentially genotoxic.
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Paxilina (alcaloide)
, Paxilline
, Paxilline (alcaloïde)
|
