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p21-aktivierte Kinasen (PAK) sind eine Enz … p21-aktivierte Kinasen (PAK) sind eine Enzymfamilie, die zu den Serin/Threonin-Proteinkinasen zählt. Dabei werden diese Kinasen durch das Protein CDK-Inhibitor 1 (p21) aktiviert. Die Aktivität von PAK1, PAK2 und PAK3 wird durch das Binden an die Rho-GTPasen und stimuliert, während PAK4, PAK5 und PAK6 unabhängig von Rho-GTPasen agieren. PAK spielen eine wichtige Rolle bei zahlreichen zellulären Prozessen, z. B. bei der Signaltransduktion, Organisation des Cytoskeletts, zellulären Morphogenese, Gentranskription und dem Überleben der Zelle.transkription und dem Überleben der Zelle.
, p21 activated kinases (PAKs) are members o … p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities. Members include:
* PAK1, regulating cell motility and morphology
* PAK2, possibly playing a role in apoptosis
* PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
* PAK4, a mediator of filopodia formation
* PAK5, a mediator of filopodia formation
* PAK6, involved in cytoskeleton rearrangementK6, involved in cytoskeleton rearrangement
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| rdfs:comment |
p21-aktivierte Kinasen (PAK) sind eine Enz … p21-aktivierte Kinasen (PAK) sind eine Enzymfamilie, die zu den Serin/Threonin-Proteinkinasen zählt. Dabei werden diese Kinasen durch das Protein CDK-Inhibitor 1 (p21) aktiviert. Die Aktivität von PAK1, PAK2 und PAK3 wird durch das Binden an die Rho-GTPasen und stimuliert, während PAK4, PAK5 und PAK6 unabhängig von Rho-GTPasen agieren. PAK spielen eine wichtige Rolle bei zahlreichen zellulären Prozessen, z. B. bei der Signaltransduktion, Organisation des Cytoskeletts, zellulären Morphogenese, Gentranskription und dem Überleben der Zelle.transkription und dem Überleben der Zelle.
, p21 activated kinases (PAKs) are members o … p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities. Members include:
* PAK1, regulating cell motility and morphology
* PAK2, possibly playing a role in apoptosis
* PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
* PAK4, a mediator of filopodia formation
* PAK5, a mediator of filopodia formation
* PAK6, involved in cytoskeleton rearrangementK6, involved in cytoskeleton rearrangement
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| rdfs:label |
P21-aktivierte Kinasen
, P21-activated kinases
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