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Les récepteurs de l'hypocrétine, également appelés récepteurs de l'orexine, sont des récepteurs couplés aux protéines G. Il existe deux variantes, chacune codée par un gène HCRTR1 et HCRTR2.
, The orexin receptor (also referred to as t … The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. Several orexin receptor antagonists are in development for potential use in sleep disorders. The first of these, suvorexant, has been on the market in the United States since 2015. There were two orexin agonists under development as of 2019.xin agonists under development as of 2019.
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| rdfs:comment |
The orexin receptor (also referred to as t … The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (HCRTR1, HCRTR2). Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors. orexin-A is equipotent at both receptors.
, Les récepteurs de l'hypocrétine, également appelés récepteurs de l'orexine, sont des récepteurs couplés aux protéines G. Il existe deux variantes, chacune codée par un gène HCRTR1 et HCRTR2.
|
| rdfs:label |
Récepteur de l'hypocrétine
, Orexin receptor
|
