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NDH-2, also known as type II NADH:quinone … NDH-2, also known as type II NADH:quinone oxidoreductase or alternative NADH dehydrogenase, is an enzyme (EC: 1.6.99.3) which catalyzes the electron transfer from NADH (electron donor) to a quinone (electron acceptor), being part of the electron transport chain. NDH-2 are peripheral membrane protein, functioning as dimers in vivo, with approximately 45 KDa per subunit and a single FAD as their cofactor. NDH-2 are the only enzymes, with NADH dehydrogenase activity, expressed in the respiratory chain of some pathogenic organisms (e.g. Staphylococcus aureus), and for that they have been proposed as new targets for rational drug design.d as new targets for rational drug design.
, NDH-2, também conhecida como NADH:quinona … NDH-2, também conhecida como NADH:quinona oxidoreductase de tipo II ou NADH desidrogenase alternativa é um enzima (EC: 1.6.99.3) que catalisa a transferência de electrões do NADH (dador) para uma quinona (aceitador), fazendo parte da cadeia de transporte electrónico . NDH-2 são enzimas membranares periféricos com aproximadamente 45 KDa por subunidade, que funcionam como dímeros in vivo e com um FAD como único grupo prostético . NDH-2 são os únicos enzimas, com actividade de NADH desidrogenase, expressos na cadeia respiratória de alguns organismos patogénicos (e.g. Staphylococcus aureus), como tal foram propostos como novos alvos terapêuticos para o design racional de novos antibióticos . o design racional de novos antibióticos .
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| rdfs:comment |
NDH-2, também conhecida como NADH:quinona … NDH-2, também conhecida como NADH:quinona oxidoreductase de tipo II ou NADH desidrogenase alternativa é um enzima (EC: 1.6.99.3) que catalisa a transferência de electrões do NADH (dador) para uma quinona (aceitador), fazendo parte da cadeia de transporte electrónico . NDH-2 são enzimas membranares periféricos com aproximadamente 45 KDa por subunidade, que funcionam como dímeros in vivo e com um FAD como único grupo prostético .e com um FAD como único grupo prostético .
, NDH-2, also known as type II NADH:quinone … NDH-2, also known as type II NADH:quinone oxidoreductase or alternative NADH dehydrogenase, is an enzyme (EC: 1.6.99.3) which catalyzes the electron transfer from NADH (electron donor) to a quinone (electron acceptor), being part of the electron transport chain. NDH-2 are peripheral membrane protein, functioning as dimers in vivo, with approximately 45 KDa per subunit and a single FAD as their cofactor.ubunit and a single FAD as their cofactor.
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| rdfs:label |
NDH-2
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