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In transplantation medicine, the Milan cri … In transplantation medicine, the Milan criteria are set of criteria applied in consideration of patients with cirrhosis and hepatocellular carcinoma (HCC) for liver transplantation with intent to cure their disease. Their significance derives from a landmark 1996 study in 48 patients by Mazzaferro et al which showed that selecting cases for transplantation according to specific strict criteria led to improved overall and disease-free survival at a four-year time point. These same criteria have since been adopted by the Organ Procurement and Transplantation Network (OPTN) in the evaluation of patients for potential transplantation.The threshold Milan criteria are as follows:
* one lesion smaller than 5 cm; alternatively, up to three lesions, each smaller than 3 cm
* no extrahepatic manifestations
* no evidence of gross vascular invasion Under current OPTN/ONUS guidelines, patients with cirrhosis and HCC who meet these criteria may be considered for transplantation. Depending on the treatment algorithm, additional factors such as advanced liver disease (as classified by Child-Pugh score) or evidence of portal hypertension may also affect suitability for transplantation.so affect suitability for transplantation.
, I criteri di Milano sono dei parametri uti … I criteri di Milano sono dei parametri utilizzati per selezionare i pazienti affetti da carcinoma epatocellulare (hepatocellular carcinoma, HCC) in cui è chirurgicamente possibile effettuare una resezione del tumore e, possibilmente, in base alla classificazione di Barcellona (BCLC) effettuare un trapianto epatico. Il trapianto di fegato rappresenta oggi il migliore trattamento per i pazienti affetti da piccoli HCC, grazie alla sua capacità di rimuovere contemporaneamente sia l'intero tumore sia il sottostante fegato cirrotico, che rappresenta una vera e propria condizione pre-cancerosa.a vera e propria condizione pre-cancerosa.
, Die Milan-Kriterien oder Mailand-Kriterien … Die Milan-Kriterien oder Mailand-Kriterien werden bei Patienten mit einem hepatozellulären Karzinom (HCC) bei gleichzeitig vorliegender Leberzirrhose angewendet. Sie dienen der Abschätzung der Erfolgsaussicht der Lebertransplantation und werden für die Listung zur Lebertransplantation verwendet. Nach wissenschaftlichen Untersuchungen sollen Patienten, die innerhalb der Milan-Kriterien transplantiert werden, ein besseres Langzeit-Überleben haben (75 % nach vier Jahren).Die Definition der Milan-Kriterien lautet wie folgt: 1.
* eine Läsion kleiner als 5 cm 2.
* bis zu drei Läsionen, jede kleiner oder nicht größer als 3 cm 3.
* keine extrahepatische Manifestation 4.
* keine vaskuläre Invasion (z. B. Tumorthrombose der Pfortader oder Lebervenen)orthrombose der Pfortader oder Lebervenen)
, En el contexto del trasplante de hígado, l … En el contexto del trasplante de hígado, los criterios de Milán, propuestos en 1996 por el equipo del , sirven como guía para seleccionar pacientes con cirrosis y hepatocarcinoma. Los criterios de Milán establecen que un paciente puede ser seleccionado para trasplante si es que cumple con una de los siguientes dos condiciones:
* Una lesión menor de 5 cm
* Hasta 3 lesiones menores de 3 cm
* Sin invasión vascular
* Sin manifestaciones extrahepáticas Actualmente el criterio histopatológico aquí expuesto es utilizado sólo en algunos centros clínicos, en donde se pone un mayor énfasis a las contraindicaciones sistémicas que pueden presentar los pacientes.émicas que pueden presentar los pacientes.
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En el contexto del trasplante de hígado, l … En el contexto del trasplante de hígado, los criterios de Milán, propuestos en 1996 por el equipo del , sirven como guía para seleccionar pacientes con cirrosis y hepatocarcinoma. Los criterios de Milán establecen que un paciente puede ser seleccionado para trasplante si es que cumple con una de los siguientes dos condiciones:
* Una lesión menor de 5 cm
* Hasta 3 lesiones menores de 3 cm
* Sin invasión vascular
* Sin manifestaciones extrahepáticasular
* Sin manifestaciones extrahepáticas
, Die Milan-Kriterien oder Mailand-Kriterien … Die Milan-Kriterien oder Mailand-Kriterien werden bei Patienten mit einem hepatozellulären Karzinom (HCC) bei gleichzeitig vorliegender Leberzirrhose angewendet. Sie dienen der Abschätzung der Erfolgsaussicht der Lebertransplantation und werden für die Listung zur Lebertransplantation verwendet. Nach wissenschaftlichen Untersuchungen sollen Patienten, die innerhalb der Milan-Kriterien transplantiert werden, ein besseres Langzeit-Überleben haben (75 % nach vier Jahren).Die Definition der Milan-Kriterien lautet wie folgt:tion der Milan-Kriterien lautet wie folgt:
, In transplantation medicine, the Milan cri … In transplantation medicine, the Milan criteria are set of criteria applied in consideration of patients with cirrhosis and hepatocellular carcinoma (HCC) for liver transplantation with intent to cure their disease. Their significance derives from a landmark 1996 study in 48 patients by Mazzaferro et al which showed that selecting cases for transplantation according to specific strict criteria led to improved overall and disease-free survival at a four-year time point. These same criteria have since been adopted by the Organ Procurement and Transplantation Network (OPTN) in the evaluation of patients for potential transplantation.The threshold Milan criteria are as follows:e threshold Milan criteria are as follows:
, I criteri di Milano sono dei parametri uti … I criteri di Milano sono dei parametri utilizzati per selezionare i pazienti affetti da carcinoma epatocellulare (hepatocellular carcinoma, HCC) in cui è chirurgicamente possibile effettuare una resezione del tumore e, possibilmente, in base alla classificazione di Barcellona (BCLC) effettuare un trapianto epatico. Il trapianto di fegato rappresenta oggi il migliore trattamento per i pazienti affetti da piccoli HCC, grazie alla sua capacità di rimuovere contemporaneamente sia l'intero tumore sia il sottostante fegato cirrotico, che rappresenta una vera e propria condizione pre-cancerosa.a vera e propria condizione pre-cancerosa.
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| rdfs:label |
Criterios de Milán
, Milan-Kriterien
, Milan criteria
, Criteri di Milano
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