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Medifoxamine, previously sold under the br … Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco. The drug was first introduced in France sometime around 1990. It was withdrawn from the market in 1999 (Morocco) and 2000 (France) following incidences of hepatotoxicity.e) following incidences of hepatotoxicity.
, Medifoxamin ist ein Arzneistoff, der vor s … Medifoxamin ist ein Arzneistoff, der vor seiner Marktrücknahme zur Behandlung von Depressionen eingesetzt wurde. Es wirkt als Dopaminwiederaufnahmehemmer und als Agonist am 5HT2A und 5HT2C-Rezeptor. Die Merck-Tochter Lipha vertrieb Medifoxamin als Bestandteil eines Arzneimittels unter dem Handelsnamen Cledial. Medifoxamin wurde hauptsächlich in Frankreich eingesetzt. 1999 wurde es vom Markt genommen, da seltene, aber schwere Fälle von Leberschädigungen bekannt wurden.älle von Leberschädigungen bekannt wurden.
, La medifoxamina è un antidepressivo che no … La medifoxamina è un antidepressivo che non appartiene né alla famiglia dei triciclici né a quella degli IMAO. Nel ratto la medifoxamina corregge i disturbi comportamentali che insorgono a seguito di ablazione dei bulbi olfattivi e antagonizza l'ipotermia e la ptosi indotte dalla reserpina.La medifoxamina non modifica l'attività locomotoria ed esplorativa dell'animale e possiede solo un debole effetto anticolinergico.Probabilmente il farmaco attiva il sistema dopaminergico, agendo come un inibitore della ricaptazione della dopamina, ed in misura minore anche quello noradrenergico. Esercita inoltre un'attività di tipo agonistico sui recettori 5-HT2A e sui recettori 5-HT2C.i recettori 5-HT2A e sui recettori 5-HT2C.
, Medifoxamina, anteriormente vendida sob as … Medifoxamina, anteriormente vendida sob as marcas Clédial e Gerdaxyl, é um antidepressivo atípico com propriedades ansiolíticas que atua por meio de mecanismos dopaminérgicos e serotonérgicos, anteriormente comercializado na França e Espanha, bem como em Marrocos. A droga foi introduzida pela primeira vez na França por volta de 1990. Foi retirado do mercado em 1999 (Marrocos) e 2000 (França) devido a uma sequência de incidentes de hepatotoxicidade.quência de incidentes de hepatotoxicidade.
, メジホキサミン（INN：medifoxamine、DCF：médifoxamine）とは、N,N-ジメチル-2,2-ジフェノキシエチルアミンの事である。 20世紀の末に、非定型抗精神病薬または抗不安薬として用いられた、薬物の1つである。
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| rdfs:comment |
Medifoxamina, anteriormente vendida sob as … Medifoxamina, anteriormente vendida sob as marcas Clédial e Gerdaxyl, é um antidepressivo atípico com propriedades ansiolíticas que atua por meio de mecanismos dopaminérgicos e serotonérgicos, anteriormente comercializado na França e Espanha, bem como em Marrocos. A droga foi introduzida pela primeira vez na França por volta de 1990. Foi retirado do mercado em 1999 (Marrocos) e 2000 (França) devido a uma sequência de incidentes de hepatotoxicidade.quência de incidentes de hepatotoxicidade.
, メジホキサミン（INN：medifoxamine、DCF：médifoxamine）とは、N,N-ジメチル-2,2-ジフェノキシエチルアミンの事である。 20世紀の末に、非定型抗精神病薬または抗不安薬として用いられた、薬物の1つである。
, La medifoxamina è un antidepressivo che no … La medifoxamina è un antidepressivo che non appartiene né alla famiglia dei triciclici né a quella degli IMAO. Nel ratto la medifoxamina corregge i disturbi comportamentali che insorgono a seguito di ablazione dei bulbi olfattivi e antagonizza l'ipotermia e la ptosi indotte dalla reserpina.La medifoxamina non modifica l'attività locomotoria ed esplorativa dell'animale e possiede solo un debole effetto anticolinergico.Probabilmente il farmaco attiva il sistema dopaminergico, agendo come un inibitore della ricaptazione della dopamina, ed in misura minore anche quello noradrenergico. Esercita inoltre un'attività di tipo agonistico sui recettori 5-HT2A e sui recettori 5-HT2C.i recettori 5-HT2A e sui recettori 5-HT2C.
, Medifoxamine, previously sold under the br … Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco. The drug was first introduced in France sometime around 1990. It was withdrawn from the market in 1999 (Morocco) and 2000 (France) following incidences of hepatotoxicity.e) following incidences of hepatotoxicity.
, Medifoxamin ist ein Arzneistoff, der vor s … Medifoxamin ist ein Arzneistoff, der vor seiner Marktrücknahme zur Behandlung von Depressionen eingesetzt wurde. Es wirkt als Dopaminwiederaufnahmehemmer und als Agonist am 5HT2A und 5HT2C-Rezeptor. Die Merck-Tochter Lipha vertrieb Medifoxamin als Bestandteil eines Arzneimittels unter dem Handelsnamen Cledial. Medifoxamin wurde hauptsächlich in Frankreich eingesetzt. 1999 wurde es vom Markt genommen, da seltene, aber schwere Fälle von Leberschädigungen bekannt wurden.älle von Leberschädigungen bekannt wurden.
|
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Medifoxamine
, Medifoxamina
, メジホキサミン
, Medifoxamin
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