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Il loxoprofene è un farmaco che possiede p … Il loxoprofene è un farmaco che possiede proprietà analgesiche, antinfiammatorie e antipiretiche. La sua attività è da 3 a 20 volte superiore a quella di ketoprofene, naproxene ed indometacina. Nell'infiammazione acuta e cronica i suoi effetti farmacologici risultano paragonabili a quelli di ketoprofene e naproxene con il vantaggio di una minore gastrolesività.Il loxoprofene sodico inibisce scarsamente la biosintesi delle prostaglandine, ma il suo principale metabolita plasmatico, l'acido (2S)-2-[4-trans-(1'R,2'S)- 2-idrossiciclopentil) metil]fenilpropionico, è un potente inibitore della cicloossigenasi. Il loxoprofene sodico è pertanto un profarmaco e ciò, associato alla bassa citotossicità diretta sulle cellule della mucosa gastrica, spiega, almeno in parte, lo scarso effetto ulcerogeno.È noto che il processo degenerativo delle cartilagini nelle articolazioni infiammate può essere accelerato da alcuni FANS. Il loxoprofene invece impedisce in vitro la degenerazione del proteoglicano e il suo metabolita attivo non mostra alcun effetto sul metabolismo del proteoglicano.effetto sul metabolismo del proteoglicano.
, 洛索洛芬（Loxoprofen）是一种非甾体抗炎药，它和布洛芬和萘普生等一樣都属于丙酸衍生物。一些国家允許洛索洛芬用於口服。1977年，洛索洛芬成為专利藥物，1986年被批准用于医疗用途。
, ロキソプロフェン（Loxoprofen）は、プロピオン酸系の解熱消炎鎮痛剤。商品名はロキソニン（Loxonin）で、第一三共が発売し、後発医薬品も各社から発売されている。現在、日本・メキシコ・ブラジルでよく使用されている抗炎症薬の一つである。
, Loxoprofen is a nonsteroidal anti-inflamma … Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006; medicated tape and gel formulations followed in 2008 and 2010. It was patented in 1977 and approved for medical use in 1986.1977 and approved for medical use in 1986.
, لوكسوبروفين (بالإنجليزية: Loxoprofen) هو دواء يُستعمل في علاج:
* التهاب حول المفصل (منذ 31 ديسمبر 2005)
, Loxoprofeno (DCI) é um anti-inflamatório n … Loxoprofeno (DCI) é um anti-inflamatório não esteroidal (AINE) derivado do ácido propiônico, do mesmo grupo do ibuprofeno e naproxeno. Possui potente ação analgésica periférica, antiinflamatória e antitérmica. É vendido em diversos países para ser administrado por via oral, sendo no mercado brasileiro conhecido como Loxonin (Sankyo). Um composto transdérmico foi aprovado para venda no Japão em janeiro de 2006.do para venda no Japão em janeiro de 2006.
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لوكسوبروفين (بالإنجليزية: Loxoprofen) هو دواء يُستعمل في علاج:
* التهاب حول المفصل (منذ 31 ديسمبر 2005)
, ロキソプロフェン（Loxoprofen）は、プロピオン酸系の解熱消炎鎮痛剤。商品名はロキソニン（Loxonin）で、第一三共が発売し、後発医薬品も各社から発売されている。現在、日本・メキシコ・ブラジルでよく使用されている抗炎症薬の一つである。
, Loxoprofen is a nonsteroidal anti-inflamma … Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006; medicated tape and gel formulations followed in 2008 and 2010. It was patented in 1977 and approved for medical use in 1986.1977 and approved for medical use in 1986.
, 洛索洛芬（Loxoprofen）是一种非甾体抗炎药，它和布洛芬和萘普生等一樣都属于丙酸衍生物。一些国家允許洛索洛芬用於口服。1977年，洛索洛芬成為专利藥物，1986年被批准用于医疗用途。
, Loxoprofeno (DCI) é um anti-inflamatório n … Loxoprofeno (DCI) é um anti-inflamatório não esteroidal (AINE) derivado do ácido propiônico, do mesmo grupo do ibuprofeno e naproxeno. Possui potente ação analgésica periférica, antiinflamatória e antitérmica. É vendido em diversos países para ser administrado por via oral, sendo no mercado brasileiro conhecido como Loxonin (Sankyo). Um composto transdérmico foi aprovado para venda no Japão em janeiro de 2006.do para venda no Japão em janeiro de 2006.
, Il loxoprofene è un farmaco che possiede p … Il loxoprofene è un farmaco che possiede proprietà analgesiche, antinfiammatorie e antipiretiche. La sua attività è da 3 a 20 volte superiore a quella di ketoprofene, naproxene ed indometacina. Nell'infiammazione acuta e cronica i suoi effetti farmacologici risultano paragonabili a quelli di ketoprofene e naproxene con il vantaggio di una minore gastrolesività.Il loxoprofene sodico inibisce scarsamente la biosintesi delle prostaglandine, ma il suo principale metabolita plasmatico, l'acido (2S)-2-[4-trans-(1'R,2'S)- 2-idrossiciclopentil) metil]fenilpropionico, è un potente inibitore della cicloossigenasi. Il loxoprofene sodico è pertanto un profarmaco e ciò, associato alla bassa citotossicità diretta sulle cellule della mucosa gastrica, spiega, almeno in parte, lo scarso effetto ulcerogeno.no in parte, lo scarso effetto ulcerogeno.
|
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洛索洛芬
, Loxoprofeno
, Loxoprofene
, ロキソプロフェン
, لوكسوبروفين
, Loxoprofen
|
