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La lactoylglutathion lyase, ou glyoxalase … La lactoylglutathion lyase, ou glyoxalase I, est une lyase qui catalyse la réaction : (R)-S-lactoylglutathion glutathion + méthylglyoxal. Cette enzyme fait partie du système glyoxalase, composé de deux enzymes cytosoliques permettant la détoxication du méthylglyoxal, un sous-produit naturel du métabolisme cependant très toxique en raison de sa forte réactivité avec les protéines, les acides nucléiques et d'autres constituants cellulaires. La seconde enzyme, l'hydroxyacylglutathion hydrolase, libère du D-lactate à partir de l'intermédiaire produit par la première réaction. Ces deux enzymes ont la particularité d'utiliser le glutathion pour former un adduit (R)-S-lactoylglutathion et non pas comme cofacteur d'oxydoréduction. L'aldose réductase peut également détoxiquer le méthylglyoxal, mais le système glyoxalase est plus efficace. La lactoylglutathion lyase est une cible privilégiée pour le développement de médicaments antiparasitaires et anticancéreux.caments antiparasitaires et anticancéreux.
, The enzyme lactoylglutathione lyase (EC 4. … The enzyme lactoylglutathione lyase (EC 4.4.1.5, also known as glyoxalase I) catalyzes the isomerization of hemithioacetal adducts, which are formed in a spontaneous reaction between a glutathionyl group and aldehydes such as methylglyoxal. (R)-S-lactoylglutathione = glutathione + 2-oxopropanal Glyoxalase I derives its name from its catalysis of the first step in the glyoxalase system, a critical two-step detoxification system for methylglyoxal. Methylglyoxal is produced naturally as a byproduct of normal biochemistry, but is highly toxic, due to its chemical reactions with proteins, nucleic acids, and other cellular components. The second detoxification step, in which (R)-S-lactoylglutathione is split into glutathione and D-lactate, is carried out by glyoxalase II, a hydrolase. Unusually, these reactions carried out by the glyoxalase system does not oxidize glutathione, which usually acts as a redox coenzyme. Although aldose reductase can also detoxify methylglyoxal, the glyoxalase system is more efficient and seems to be the most important of these pathways. Glyoxalase I is an attractive target for the development of drugs to treat infections by some parasitic protozoa, and cancer. Several inhibitors of glyoxalase I have been identified, such as S-(N-hydroxy-N-methylcarbamoyl)glutathione. Glyoxalase I is classified as a carbon-sulfur lyase although, strictly speaking, the enzyme does not form or break a carbon-sulfur bond. Rather, the enzyme shifts two hydrogen atoms from one carbon atom of the methylglyoxal to the adjacent carbon atom. In effect, the reaction is an intramolecular redox reaction; one carbon is oxidized whereas the other is reduced. The mechanism proceeds by subtracting and then adding protons, forming an enediolate intermediate, rather than by transferring hydrides. Unusually for a metalloprotein, this enzyme shows activity with several different metals. Glyoxalase I is also unusual in that it is stereospecific in the second half of its mechanism, but not in the first half. Structurally, the enzyme is a domain-swapped dimer in many species, although the two subunits have merged into a monomer in yeast, through gene duplication.onomer in yeast, through gene duplication.
, GLO1 (англ. Glyoxalase I) – білок, який ко … GLO1 (англ. Glyoxalase I) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 184 амінокислот, а молекулярна маса — 20 778. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до ліаз, фосфопротеїнів. Задіяний у таких біологічних процесах, як ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з іонами металів, іоном цинку.зв'язування з іонами металів, іоном цинку.
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Ribbon diagram of human glyoxalase I with … Ribbon diagram of human glyoxalase I with its catalytic zinc ions shown as two purple spheres. An inhibitor, S-hexylglutathione, is shown as a space-filling model; the green, red, blue and yellow spheres correspond to carbon, oxygen, nitrogen and sulfur atoms, respectively., nitrogen and sulfur atoms, respectively.
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The enzyme lactoylglutathione lyase (EC 4. … The enzyme lactoylglutathione lyase (EC 4.4.1.5, also known as glyoxalase I) catalyzes the isomerization of hemithioacetal adducts, which are formed in a spontaneous reaction between a glutathionyl group and aldehydes such as methylglyoxal. (R)-S-lactoylglutathione = glutathione + 2-oxopropanallglutathione = glutathione + 2-oxopropanal
, La lactoylglutathion lyase, ou glyoxalase … La lactoylglutathion lyase, ou glyoxalase I, est une lyase qui catalyse la réaction : (R)-S-lactoylglutathion glutathion + méthylglyoxal. Cette enzyme fait partie du système glyoxalase, composé de deux enzymes cytosoliques permettant la détoxication du méthylglyoxal, un sous-produit naturel du métabolisme cependant très toxique en raison de sa forte réactivité avec les protéines, les acides nucléiques et d'autres constituants cellulaires. La seconde enzyme, l'hydroxyacylglutathion hydrolase, libère du D-lactate à partir de l'intermédiaire produit par la première réaction. Ces deux enzymes ont la particularité d'utiliser le glutathion pour former un adduit (R)-S-lactoylglutathion et non pas comme cofacteur d'oxydoréduction. non pas comme cofacteur d'oxydoréduction.
, GLO1 (англ. Glyoxalase I) – білок, який ко … GLO1 (англ. Glyoxalase I) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 184 амінокислот, а молекулярна маса — 20 778. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: ТирозиннT: ТреонінV: ВалінW: Триптофан Y: Тирозин
|
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Lactoylglutathion lyase
, GLO1
, Lactoylglutathione lyase
|
