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락토페리신(lactoferricin)은 , 양이온성의 펩타이드로 항미생물, … 락토페리신(lactoferricin)은 , 양이온성의 펩타이드로 항미생물, 항암 능력을 가지고 있다. 락토페린이 펩신에 의해 매개되는 단백질분해를 거쳐 락토페리신이 생성된다. 젖의 단백질에서 유래하는 항미생물 펩타이드 중 가장 많이 연구되었다. 락토페리신의 완전한 서열은 락토페린의 17-41번 아미노산 잔기(FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084 Archived 2018년 11월 3일 - 웨이백 머신)에 대응하며 이 부분 안의 서열 역시 항미생물 활성을 가진다. MilkAMP 데이터베이스에는 완전한 락토페리신을 구성하고 있거나, 락토페리신에서 유래한 총 111개의 펩타이드(자연적인 경우, 합성된 경우, 변형된 경우 모두 포함)가 등록되어 있다. 사람의 락토페리신은 락토페린의 1-47번 잔기에 대응하지만 1-11과 12-47의 두 소단위체로 구성되어 있다. (LFH0009 Archived 2017년 1월 13일 - 웨이백 머신) 두 소단위체는 서로 이황화 결합으로 연결되어 있다. 사람과 소의 락토페리신은 락토페리신 중에서 가장 많이 연구된 두 형태이다. 이 두 형태의 락토페리신의 서열에는 많은 차이가 존재한다. 소 락토페리신은 25개의 아미노산 잔기를 포함하고 있지만 사람 락토페리신은 49개의 아미노산 잔기로 이루어져 있다. 또한 용액에 넣었을 때 소 락토페리신은 베타 병풍을 형성하지만 사람 락토페리신은 코일 구조를 이룬다. 락토페리신은 베타 병풍을 형성하지만 사람 락토페리신은 코일 구조를 이룬다.
, Lactoferricin is an amphipathic, cationic … Lactoferricin is an amphipathic, cationic peptide with anti-microbial and anti-cancer properties. It can be generated by the pepsin-mediated digestion of lactoferrin. Lactoferricin is the most studied AMP derived from milk protein. The complete sequence of lactoferricin corresponds to lactoferrin fragment 17-41 (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084) and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural, synthetic and modified) comprising or derived from the complete lactoferricin. In humans, lactoferricin corresponds to lactoferrin fragment 1-47 but consists of two subunits, namely fragments 1-11 and 12-47 (LFH0009), connected by a disulfide bridge. Human Lactoferricin and Bovine Lactoferricin are two greatly studied forms of Lactoferricin. These two forms have great sequence differences. Bovine Lactoferricin contains 25 residues, while Human Lactoferricin contains 49 residues. Also, when placed in solution Bovine Lactoferricin forms a β-pleated sheet, while Human Lactoferricin forms a coiled structure.an Lactoferricin forms a coiled structure.
, Lactoferricina es un péptido anfipático, c … Lactoferricina es un péptido anfipático, catiónico, de propiedades antimicrobianas y anticancerígenas. Puede generarse por medio de la digestión de la lactoferrina. La lactoferricina es el derivado péptido antimicrobiano anfipático (AMP en inglés) más estudiado de proteína de la leche. Su secuencia completa corresponde al fragmento 17-41 de la lactoferrina (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084 Archivado el 3 de noviembre de 2018 en Wayback Machine.). Secuencias internas de este fragmento son también antimicrobianas. La base de datos MilkAMP contiene un total de 111 péptidos (naturales, sintéticos y modificados) comprendidos o derivados de la lactoferricina completa. En humanos, la lactoferricina corresponde al fragmento 1-47 de la lactoferrina, pero consta de dos subunidades: los fragmentos 1-11 y 12-47 (LFH0009 Archivado el 13 de enero de 2017 en Wayback Machine.), conectados por un puente de disulfuro. Dos variantes ampliamente estudiadas de lactoferricina son la humana y la bovina. Sus secuencias difieren notablemente: con respecto a residuos, la bovina contiene 25; la humana, 49. En solución, la bovina forma láminas beta, y la humana genera una estructura enrollada.a humana genera una estructura enrollada.
, Laktoferycyna (ang. lactoferricin) – wystę … Laktoferycyna (ang. lactoferricin) – występujący naturalnie, amfipatyczny, kationowy peptyd, pochodny laktoferyny. Ma właściwości przeciwbakteryjne, przeciwnowotworowe i immunomodulujące. Powstaje w przewodzie pokarmowym pod wpływem enzymu proteolitycznego pepsyny, która odcina fragment N-końca z obecnego w mleku i płynach ustrojowych białka – laktoferyny. Ludzka laktoferycyna to peptyd identyczny z fragmentem 1-47 laktoferyny. Ma dwie podjednostki i dwa łączące mostki dwusiarczkowe.nostki i dwa łączące mostki dwusiarczkowe.
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| rdfs:comment |
Lactoferricina es un péptido anfipático, c … Lactoferricina es un péptido anfipático, catiónico, de propiedades antimicrobianas y anticancerígenas. Puede generarse por medio de la digestión de la lactoferrina. La lactoferricina es el derivado péptido antimicrobiano anfipático (AMP en inglés) más estudiado de proteína de la leche. Su secuencia completa corresponde al fragmento 17-41 de la lactoferrina (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084 Archivado el 3 de noviembre de 2018 en Wayback Machine.). Secuencias internas de este fragmento son también antimicrobianas. La base de datos MilkAMP contiene un total de 111 péptidos (naturales, sintéticos y modificados) comprendidos o derivados de la lactoferricina completa. En humanos, la lactoferricina corresponde al fragmento 1-47 de la lactoferrina, pero consta de dos subunidades: los fragmenero consta de dos subunidades: los fragmen
, Lactoferricin is an amphipathic, cationic … Lactoferricin is an amphipathic, cationic peptide with anti-microbial and anti-cancer properties. It can be generated by the pepsin-mediated digestion of lactoferrin. Lactoferricin is the most studied AMP derived from milk protein. The complete sequence of lactoferricin corresponds to lactoferrin fragment 17-41 (FKCRRWQWRM KKLGAPSITCVRRAF; LFB0084) and sequences from within this fragment are also antimicrobial. The MilkAMP database contains a total of 111 peptides (natural, synthetic and modified) comprising or derived from the complete lactoferricin. In humans, lactoferricin corresponds to lactoferrin fragment 1-47 but consists of two subunits, namely fragments 1-11 and 12-47 (LFH0009), connected by a disulfide bridge.LFH0009), connected by a disulfide bridge.
, Laktoferycyna (ang. lactoferricin) – wystę … Laktoferycyna (ang. lactoferricin) – występujący naturalnie, amfipatyczny, kationowy peptyd, pochodny laktoferyny. Ma właściwości przeciwbakteryjne, przeciwnowotworowe i immunomodulujące. Powstaje w przewodzie pokarmowym pod wpływem enzymu proteolitycznego pepsyny, która odcina fragment N-końca z obecnego w mleku i płynach ustrojowych białka – laktoferyny. Ludzka laktoferycyna to peptyd identyczny z fragmentem 1-47 laktoferyny. Ma dwie podjednostki i dwa łączące mostki dwusiarczkowe.nostki i dwa łączące mostki dwusiarczkowe.
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| rdfs:label |
Lactoferricina
, Lactoferricin
, 락토페리신
, Laktoferycyna
|
