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KcsA (K channel of streptomyces A) is a pr … KcsA (K channel of streptomyces A) is a prokaryotic potassium channel from the soil bacterium Streptomyces lividans that has been studied extensively in ion channel research. The pH activated protein possesses two transmembrane segments and a highly selective pore region, responsible for the gating and shuttling of K+ ions out of the cell. The amino acid sequence found in the selectivity filter of KcsA is highly conserved among both prokaryotic and eukaryotic K+ voltage channels; as a result, research on KcsA has provided important structural and mechanistic insight on the molecular basis for K+ ion selection and conduction. As one of the most studied ion channels to this day, KcsA is a template for research on K+ channel function and its elucidated structure underlies computational modeling of channel dynamics for both prokaryotic and eukaryotic species.r both prokaryotic and eukaryotic species.
, KcsA (abreviatura do inglês, K channel of … KcsA (abreviatura do inglês, K channel of streptomyces A) é um canal de potássio de procariotos presentes em bactérias do solo Streptomyces lividans. A proteína é ativada por pH e possui dois segmentos transmembrana com uma região de poro altamente seletiva, responsável pela passagem e transporte de íons potássio (K+) para fora da célula. A sequência de aminoácidos encontrada no filtro de seletividade de KcsA é altamente conservada entre os canais de voltagem de K+ de procariotos e eucariotos; como resultado, a pesquisa sobre KcsA forneceu uma visão estrutural e mecanística importante na base molecular para a seleção e condução de íons K+. Como um dos canais iônicos mais estudados até hoje, KcsA é um modelo para a pesquisa sobre a função do canal de K+ e sua estrutura elucidada é usada de base para a modelagem computacional da dinâmica do canal para outras espécies.da dinâmica do canal para outras espécies.
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KcsA
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The four subunits forming the channel are drawn in different colors. They surround a central pore, guarded by the selectivity filter made up of the P-loops from each of the subunits. The blue and red dots indicate the boundaries of the lipid bilayer.
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IPR013099
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| rdfs:comment |
KcsA (abreviatura do inglês, K channel of … KcsA (abreviatura do inglês, K channel of streptomyces A) é um canal de potássio de procariotos presentes em bactérias do solo Streptomyces lividans. A proteína é ativada por pH e possui dois segmentos transmembrana com uma região de poro altamente seletiva, responsável pela passagem e transporte de íons potássio (K+) para fora da célula. A sequência de aminoácidos encontrada no filtro de seletividade de KcsA é altamente conservada entre os canais de voltagem de K+ de procariotos e eucariotos; como resultado, a pesquisa sobre KcsA forneceu uma visão estrutural e mecanística importante na base molecular para a seleção e condução de íons K+. Como um dos canais iônicos mais estudados até hoje, KcsA é um modelo para a pesquisa sobre a função do canal de K+ e sua estrutura elucidada é usada de e K+ e sua estrutura elucidada é usada de
, KcsA (K channel of streptomyces A) is a pr … KcsA (K channel of streptomyces A) is a prokaryotic potassium channel from the soil bacterium Streptomyces lividans that has been studied extensively in ion channel research. The pH activated protein possesses two transmembrane segments and a highly selective pore region, responsible for the gating and shuttling of K+ ions out of the cell. The amino acid sequence found in the selectivity filter of KcsA is highly conserved among both prokaryotic and eukaryotic K+ voltage channels; as a result, research on KcsA has provided important structural and mechanistic insight on the molecular basis for K+ ion selection and conduction. As one of the most studied ion channels to this day, KcsA is a template for research on K+ channel function and its elucidated structure underlies computational modelid structure underlies computational modeli
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| rdfs:label |
KcsA potassium channel
, Canal de potássio KcsA
|
