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|
JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(t … JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(trifluoromethyl)phenyl]pyrrol-3-yl]methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent and selective agonist of the CB2 receptor. JWH-372 binds approximately 9 times stronger to the CB2 receptor (Ki = 8.2 ± 0.2nM) than the CB1 receptor (Ki = 77 ± 2nM). The selectivity of JWH-372 for the CB2 receptor is likely due to the electron-withdrawing character of the trifluoromethyl group rather than steric effects, as the o-methyl compound JWH-370 was only mildly selective for the CB2 receptor (CB1 Ki = 5.6 ± 0.4nM, CB2 Ki = 4.0 ± 0.5nM).1 Ki = 5.6 ± 0.4nM, CB2 Ki = 4.0 ± 0.5nM).
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914458-28-9
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44418325
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4244
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1102142867
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http://dbpedia.org/resource/Category:Designer_drugs +
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, http://dbpedia.org/resource/Synthetic_cannabinoid +
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, http://dbpedia.org/resource/Controlled_Drugs_and_Substances_Act +
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|
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27
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914458
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23277903
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3
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24
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|
naphthalen-1-yl-[1-pentyl-5-[2-phenyl]pyrrol-3-yl]methanone
|
| http://dbpedia.org/property/legalCa
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Schedule II
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Class B
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1
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1
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44418325
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CCCCCN1C=CCC3=CC=CC4=CC=CC=C43
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1
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CYPUIQJYGVOHMM-UHFFFAOYSA-N
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http://dbpedia.org/resource/Category:CB2_receptor_agonists +
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|
| rdfs:comment |
JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(t … JWH-372 (naphthalen-1-yl-[1-pentyl-5-[2-(trifluoromethyl)phenyl]pyrrol-3-yl]methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as a potent and selective agonist of the CB2 receptor. JWH-372 binds approximately 9 times stronger to the CB2 receptor (Ki = 8.2 ± 0.2nM) than the CB1 receptor (Ki = 77 ± 2nM). The selectivity of JWH-372 for the CB2 receptor is likely due to the electron-withdrawing character of the trifluoromethyl group rather than steric effects, as the o-methyl compound JWH-370 was only mildly selective for the CB2 receptor (CB1 Ki = 5.6 ± 0.4nM, CB2 Ki = 4.0 ± 0.5nM).1 Ki = 5.6 ± 0.4nM, CB2 Ki = 4.0 ± 0.5nM).
|
| rdfs:label |
JWH-372
|
