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JWH-098 – organiczny związek chemiczny, syntetyczny kanabinoid otrzymany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2015 roku znajduje się w grupie I-N wykazu środków odurzających.
, JWH-098 is a synthetic cannabinoid recepto … JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around ten fold selective for CB1 over CB2, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding., but often at the expense of CB1 binding.
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| rdfs:comment |
JWH-098 – organiczny związek chemiczny, syntetyczny kanabinoid otrzymany przez Johna W. Huffmana (stąd akronim JWH). W Polsce od 2015 roku znajduje się w grupie I-N wykazu środków odurzających.
, JWH-098 is a synthetic cannabinoid recepto … JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around ten fold selective for CB1 over CB2, in JWH-098 this is reversed, and it is around four times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding., but often at the expense of CB1 binding.
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JWH-098
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