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Unter Immunoevasinen versteht man Proteine … Unter Immunoevasinen versteht man Proteine, welche es Viren erlauben, die Immunreaktion ihres Wirtes zu unterdrücken oder zu umgehen. Viele Virenfamilien besitzen eigene Immunoevasine, deren Mechanismen in vier Hauptklassen eingeteilt werden können (hier auf und -präsentation bezogen):
* Verhindern des Eintritts des Antigen-Peptids ins endoplasmatische Reticulum (ER)
* Zurückhalten der MHC-Klasse-I-Komplexe im ER
* Abbau der MHC-Klasse-I-Komplexe
* Binden der MHC-Klasse-I-Komplexe an die ZelloberflächeHC-Klasse-I-Komplexe an die Zelloberfläche
, Immunoevasins are proteins expressed by so … Immunoevasins are proteins expressed by some viruses that enable the virus to evade immune recognition by interfering with MHC I complexes in the infected cell, therefore blocking the recognition of viral protein fragments by CD8+ cytotoxic T lymphocytes. Less frequently, MHC II antigen presentation and induced-self molecules may also be targeted. Some viral immunoevasins block peptide entry into the endoplasmic reticulum (ER) by targeting the TAP transporters. Immunoevasins are particularly abundant in viruses that are capable of establishing long-term infections of the host, such as herpesviruses.ctions of the host, such as herpesviruses.
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| rdfs:comment |
Immunoevasins are proteins expressed by so … Immunoevasins are proteins expressed by some viruses that enable the virus to evade immune recognition by interfering with MHC I complexes in the infected cell, therefore blocking the recognition of viral protein fragments by CD8+ cytotoxic T lymphocytes. Less frequently, MHC II antigen presentation and induced-self molecules may also be targeted. Some viral immunoevasins block peptide entry into the endoplasmic reticulum (ER) by targeting the TAP transporters. Immunoevasins are particularly abundant in viruses that are capable of establishing long-term infections of the host, such as herpesviruses.ctions of the host, such as herpesviruses.
, Unter Immunoevasinen versteht man Proteine … Unter Immunoevasinen versteht man Proteine, welche es Viren erlauben, die Immunreaktion ihres Wirtes zu unterdrücken oder zu umgehen. Viele Virenfamilien besitzen eigene Immunoevasine, deren Mechanismen in vier Hauptklassen eingeteilt werden können (hier auf und -präsentation bezogen):
* Verhindern des Eintritts des Antigen-Peptids ins endoplasmatische Reticulum (ER)
* Zurückhalten der MHC-Klasse-I-Komplexe im ER
* Abbau der MHC-Klasse-I-Komplexe
* Binden der MHC-Klasse-I-Komplexe an die ZelloberflächeHC-Klasse-I-Komplexe an die Zelloberfläche
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Immunoevasine
, Immunoevasin
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