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HDMP-28 or methylnaphthidate is a piperidi … HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 has high affinity to SERT, and so behaves as a triple reuptake inhibitor. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration. = low propensity for self-administration.
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rdfs:comment |
HDMP-28 or methylnaphthidate is a piperidi … HDMP-28 or methylnaphthidate is a piperidine based stimulant drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate. D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT. A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration. = low propensity for self-administration.
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rdfs:label |
HDMP-28
|