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Group II introns are a large class of self … Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to site-specifically insert into DNA sites has been exploited as a tool for biotechnology. For example, group II introns can be modified to make site-specific genome insertions and deliver cargo DNA such as reporter genes or lox sitesgo DNA such as reporter genes or lox sites
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Domain_X
, GIIM
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http://commons.wikimedia.org/wiki/Special:FilePath/IntronGroupII.jpg?width=300 +
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14774
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1112937161
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http://dbpedia.org/property/caption
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full secondary structure of group II intron
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http://dbpedia.org/property/extra
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300.0
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http://dbpedia.org/property/interpro
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IPR013597
, IPR024937
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http://dbpedia.org/property/name
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Group II catalytic intron, D1-D4
, Group II intron, maturase-specific
, Group II catalytic intron, D5
, Domain X
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http://dbpedia.org/property/pdb
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4
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PF08388
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CL0359
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http://dbpedia.org/property/rfam
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RF00029
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http://dbpedia.org/property/rfamClan
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CL00102
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http://dbpedia.org/property/symbol
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Intron_gpII
, GIIM
, Domain_X
, group-II-D1D4
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rdfs:comment |
Group II introns are a large class of self … Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life. Ribozyme activity (e.g., self-splicing) can occur under high-salt conditions in vitro. However, assistance from proteins is required for in vivo splicing. In contrast to group I introns, intron excision occurs in the absence of GTP and involves the formation of a lariat, with an A-residue branchpoint strongly resembling that found in lariats formed during splicing of nuclear pre-mRNA. It is hypothesized that pre-mRNA splicing (see spliceosome) may have evolved from group II introns, due to the similar catalytic mechanism as well as the structural similarity of the Group II Domain V substructure to the U6/U2 extended snRNA. Finally, their ability to extended snRNA. Finally, their ability to
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rdfs:label |
Group II intron
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