| http://dbpedia.org/ontology/abstract
|
Gonadotropin-releasing hormone antagonists … Gonadotropin-releasing hormone antagonists (GnRH antagonists) are a class of medications that antagonize the gonadotropin-releasing hormone receptor (GnRH receptor) and thus the action of gonadotropin-releasing hormone (GnRH). They are used in the treatment of prostate cancer, endometriosis, uterine fibroids, female infertility in assisted reproduction, and for other indications. Some GnRH antagonists, such as cetrorelix, are similar in structure to natural GnRH (a hormone made by neurons in the hypothalamus) but that have an antagonistic effect, while other GnRH antagonists, such as elagolix and relugolix, are non-peptide and small-molecule compounds. GnRH antagonists compete with natural GnRH for binding to GnRH receptors, thus decreasing or blocking GnRH action in the body.asing or blocking GnRH action in the body.
, مُضَادُّ مُوَجِّهَةِ الغُدَّدِ التَّنَاسُل … مُضَادُّ مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة هي فئة من الأدوية التي تُعادي مُستقبِل الهرمون المُطْلِقُ لمُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة (بالإنجليزية: GnRH receptor) وكذلك عملية إفرازهرمون الغدد التناسلية .تُستخدَم هذه المضادات في علاج سرطان البروستاتا، والتهاب بطانة الرحم، والأورام الليفية الرحمية، والعقم لدى النساء من خلال عمليات التنقيح للمساعدة على الإنجاب، ولأي أعراض أخرى. تتشابه بعض مضادات مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة، مثل: سيتروريليكس Cetrorelix، مع الهرمون المُطْلِقُ لمُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة في بنيته الطبيعية (وهو هرمون يتكون من الخلايا العصبية الموجودة تحت المهاد) ولكن لها تأثير مضاد. بينما تتكون مضادات مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة الأخرى، مثل: إلاجوليكس Elagolix، من جزيئات صغيرة وتركيبات غير ببتيدية. تتصارع مضادات مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة مع مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة الطبيعية للارتباط بمستقبلات مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة، وتباعًا تُساعد على الحد من عمل مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة أو منعها في الجسم.ُدَّدِ التَّنَاسُلِيَّة أو منعها في الجسم.
, Gli antagonisti dell'ormone di rilascio de … Gli antagonisti dell'ormone di rilascio delle gonadotropine (ad esempio degarelix e abarelix), sono peptidi sintetici che competono con il GnRH (dall'inglese Gonadotropin Releasing Hormone, ovvero ormone liberante gonadotropine) per il suo recettore, diminuendo o annullandone del tutto l'azione del . Il risultato di ciò il rilascio endogeno, da parte della parte anteriore ipofisi, degli ormoni luteinizzante (o LH) e follicolo-stimolante (o FSH) viene inibito. Gli antagonisti del GnHR sono altresì derivati del decapeptide naturale GnRH con multiple sostituzioni aminoacidiche che modificano l'azione della molecola conferendole le proprietà di bloccare il recettore e la secrezione delle gonadotropine (LH ed FSH appunto) nel giro di poche ore. Contrariamente agli agonisti del GnRH, gli antagonisti raggiungono il loro effetto terapeutico in tempi molto rapidi; tuttavia la loro azione ha una breve emivita ed è pertanto necessario praticare iniezioni giornaliere per mantenere l'effetto. Dopo circa 40 ore dalla cessazione della somministrazione degli antagonisti del GnHR, l'attività endogena di Lh e FSH ritorna a manifestarsi anche se, bisogna attendere più a lungo affinché si raggiunga la piena funzionalità ipofisaria. L'applicazione principale di tali sostanze è attualmente l'uso a breve termine nella prevenzione dell'ovulazione endogena in pazienti sotto stimolazione esogena con FSH in preparazione della fecondazione in vitro. La somministrazione avviene nella fase follicolare intermedia o tardiva mediante cicli stimolati prima della somministrazione di gonadotropina corionica.mministrazione di gonadotropina corionica.
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/Cetrorelix.svg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageExternalLink
|
http://www.degarelix.com/ +
, http://www.ebfertility.com/ +
, http://www.fertilityauthority.com/ +
, http://www.fertilitylifelines.com/ +
|
| http://dbpedia.org/ontology/wikiPageID
|
3380832
|
| http://dbpedia.org/ontology/wikiPageLength
|
19248
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1097891508
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Precocious_puberty +
, http://dbpedia.org/resource/Linzagolix +
, http://dbpedia.org/resource/Sex_hormone +
, http://dbpedia.org/resource/Degarelix +
, http://dbpedia.org/resource/Peptide +
, http://dbpedia.org/resource/Pituitary_gland +
, http://dbpedia.org/resource/Gonadotropin-releasing_hormone_receptor +
, http://dbpedia.org/resource/Category:Antigonadotropins +
, http://dbpedia.org/resource/Breast_cancer +
, http://dbpedia.org/resource/Uterine_fibroid +
, http://dbpedia.org/resource/Relugolix +
, http://dbpedia.org/resource/GnRH_analogue +
, http://dbpedia.org/resource/Gonadotropin-releasing_hormone_modulator +
, http://dbpedia.org/resource/Transgender_youth +
, http://dbpedia.org/resource/Prostate_cancer +
, http://dbpedia.org/resource/Infertility +
, http://dbpedia.org/resource/Category:Antiestrogens +
, http://dbpedia.org/resource/Non-peptide +
, http://dbpedia.org/resource/Hot_flushes +
, http://dbpedia.org/resource/GnRH_receptor +
, http://dbpedia.org/resource/Ornirelix +
, http://dbpedia.org/resource/Teverelix +
, http://dbpedia.org/resource/Azaline_B +
, http://dbpedia.org/resource/Iturelix +
, http://dbpedia.org/resource/Receptor_antagonist +
, http://dbpedia.org/resource/Weight_gain +
, http://dbpedia.org/resource/Transgender +
, http://dbpedia.org/resource/Cetrorelix +
, http://dbpedia.org/resource/Headache +
, http://dbpedia.org/resource/Fertility_treatment +
, http://dbpedia.org/resource/Small-molecule +
, http://dbpedia.org/resource/Biosynthesis +
, http://dbpedia.org/resource/Abarelix +
, http://dbpedia.org/resource/Puberty_blocker +
, http://dbpedia.org/resource/Nausea +
, http://dbpedia.org/resource/Bone_pain +
, http://dbpedia.org/resource/GnRH_Neuron +
, http://dbpedia.org/resource/Tumor +
, http://dbpedia.org/resource/Hypothalamic%E2%80%93pituitary%E2%80%93gonadal_axis +
, http://dbpedia.org/resource/Acyline +
, http://dbpedia.org/resource/Benign_prostatic_hyperplasia +
, http://dbpedia.org/resource/Category:Gonadotropin-releasing_hormone_and_gonadotropins +
, http://dbpedia.org/resource/Hormone +
, http://dbpedia.org/resource/Gonadotropins +
, http://dbpedia.org/resource/Ozarelix +
, http://dbpedia.org/resource/Urethral_obstruction +
, http://dbpedia.org/resource/Gonadotropin-releasing_hormone_agonist +
, http://dbpedia.org/resource/Testes +
, http://dbpedia.org/resource/In-vitro_fertilization +
, http://dbpedia.org/resource/Subcutaneous_injection +
, http://dbpedia.org/resource/Ovaries +
, http://dbpedia.org/resource/Intramuscular_injection +
, http://dbpedia.org/resource/Luteinizing_hormone +
, http://dbpedia.org/resource/Spinal_cord_compression +
, http://dbpedia.org/resource/Controlled_ovarian_hyperstimulation +
, http://dbpedia.org/resource/Category:Human_female_endocrine_system +
, http://dbpedia.org/resource/Oral_administration +
, http://dbpedia.org/resource/Estradiol +
, http://dbpedia.org/resource/Elagolix +
, http://dbpedia.org/resource/Endometriosis +
, http://dbpedia.org/resource/Female_infertility +
, http://dbpedia.org/resource/Competitive_inhibition +
, http://dbpedia.org/resource/Follicular_phase +
, http://dbpedia.org/resource/Assisted_reproduction +
, http://dbpedia.org/resource/Category:GnRH_antagonists +
, http://dbpedia.org/resource/Gonad +
, http://dbpedia.org/resource/Gonadotropin-releasing_hormone +
, http://dbpedia.org/resource/Uterine_fibroids +
, http://dbpedia.org/resource/Anterior_pituitary +
, http://dbpedia.org/resource/Progesterone +
, http://dbpedia.org/resource/Category:Antiandrogens +
, http://dbpedia.org/resource/Contraceptive +
, http://dbpedia.org/resource/Castration +
, http://dbpedia.org/resource/Follicle-stimulating_hormone +
, http://dbpedia.org/resource/Ganirelix +
, http://dbpedia.org/resource/Category:Hormonal_antineoplastic_drugs +
, http://dbpedia.org/resource/Prostate-specific_antigen +
, http://dbpedia.org/resource/Testosterone +
, http://dbpedia.org/resource/Antiandrogen +
, http://dbpedia.org/resource/Ovulation +
|
| http://dbpedia.org/property/biologicalTarget
|
http://dbpedia.org/resource/GnRH_receptor +
|
| http://dbpedia.org/property/caption
|
Cetrorelix, one of the most widely used antagonists.
|
| http://dbpedia.org/property/chemicalClass
|
Peptides; Non-peptides
|
| http://dbpedia.org/property/synonyms
|
GnRH receptor antagonists; GnRH blockers; GnRH inhibitors; Antigonadotropins
|
| http://dbpedia.org/property/use
|
Infertility; Prostate cancer; Precocious puberty; Breast cancer; Endometriosis; Uterine fibroids; Transgender people
|
| http://dbpedia.org/property/width
|
250
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:No_selflink +
, http://dbpedia.org/resource/Template:Hormone_levels_with_gonadotropin-releasing_hormone_agonists_and_antagonists +
, http://dbpedia.org/resource/Template:Primary_sources +
, http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Infobox_drug_class +
, http://dbpedia.org/resource/Template:GnRH_and_gonadotropin_receptor_modulators +
, http://dbpedia.org/resource/Template:GnRH_and_gonadotropins +
, http://dbpedia.org/resource/Template:Short_description +
, http://dbpedia.org/resource/Template:Small +
, http://dbpedia.org/resource/Template:Further +
, http://dbpedia.org/resource/Template:Sub +
, http://dbpedia.org/resource/Template:Abbr +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Antiandrogens +
, http://dbpedia.org/resource/Category:Hormonal_antineoplastic_drugs +
, http://dbpedia.org/resource/Category:Antigonadotropins +
, http://dbpedia.org/resource/Category:GnRH_antagonists +
, http://dbpedia.org/resource/Category:Gonadotropin-releasing_hormone_and_gonadotropins +
, http://dbpedia.org/resource/Category:Human_female_endocrine_system +
, http://dbpedia.org/resource/Category:Antiestrogens +
|
| http://purl.org/linguistics/gold/hypernym
|
http://dbpedia.org/resource/Drugs +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone_antagonist?oldid=1097891508&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/Cetrorelix.svg +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone_antagonist +
|
| owl:sameAs |
http://rdf.freebase.com/ns/m.098mdj +
, http://vi.dbpedia.org/resource/Ch%E1%BA%A5t_%C4%91%E1%BB%91i_kh%C3%A1ng_hormone_gi%E1%BA%A3i_ph%C3%B3ng_gonadotropin +
, http://yago-knowledge.org/resource/Gonadotropin-releasing_hormone_antagonist +
, http://dbpedia.org/resource/Gonadotropin-releasing_hormone_antagonist +
, https://global.dbpedia.org/id/3L5sX +
, http://www.wikidata.org/entity/Q3618379 +
, http://ar.dbpedia.org/resource/%D9%85%D8%B6%D8%A7%D8%AF_%D9%85%D9%88%D8%AC%D9%87%D8%A9_%D8%A7%D9%84%D8%BA%D8%AF%D8%AF_%D8%A7%D9%84%D8%AA%D9%86%D8%A7%D8%B3%D9%84%D9%8A%D8%A9 +
, http://it.dbpedia.org/resource/Antagonista_dell%27ormone_di_rilascio_delle_gonadotropine +
|
| rdf:type |
http://dbpedia.org/class/yago/PhysicalEntity100001930 +
, http://dbpedia.org/class/yago/Part113809207 +
, http://dbpedia.org/class/yago/BodySubstance105263850 +
, http://dbpedia.org/class/yago/Secretion105404728 +
, http://dbpedia.org/class/yago/WikicatHormones +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/ontology/Drug +
, http://dbpedia.org/class/yago/Substance100019613 +
, http://dbpedia.org/class/yago/Matter100020827 +
, http://dbpedia.org/class/yago/Relation100031921 +
, http://dbpedia.org/class/yago/LiquidBodySubstance105397468 +
, http://dbpedia.org/class/yago/Hormone105407119 +
|
| rdfs:comment |
Gli antagonisti dell'ormone di rilascio de … Gli antagonisti dell'ormone di rilascio delle gonadotropine (ad esempio degarelix e abarelix), sono peptidi sintetici che competono con il GnRH (dall'inglese Gonadotropin Releasing Hormone, ovvero ormone liberante gonadotropine) per il suo recettore, diminuendo o annullandone del tutto l'azione del . Il risultato di ciò il rilascio endogeno, da parte della parte anteriore ipofisi, degli ormoni luteinizzante (o LH) e follicolo-stimolante (o FSH) viene inibito.ollicolo-stimolante (o FSH) viene inibito.
, Gonadotropin-releasing hormone antagonists … Gonadotropin-releasing hormone antagonists (GnRH antagonists) are a class of medications that antagonize the gonadotropin-releasing hormone receptor (GnRH receptor) and thus the action of gonadotropin-releasing hormone (GnRH). They are used in the treatment of prostate cancer, endometriosis, uterine fibroids, female infertility in assisted reproduction, and for other indications.d reproduction, and for other indications.
, مُضَادُّ مُوَجِّهَةِ الغُدَّدِ التَّنَاسُل … مُضَادُّ مُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة هي فئة من الأدوية التي تُعادي مُستقبِل الهرمون المُطْلِقُ لمُوَجِّهَةِ الغُدَّدِ التَّنَاسُلِيَّة (بالإنجليزية: GnRH receptor) وكذلك عملية إفرازهرمون الغدد التناسلية .تُستخدَم هذه المضادات في علاج سرطان البروستاتا، والتهاب بطانة الرحم، والأورام الليفية الرحمية، والعقم لدى النساء من خلال عمليات التنقيح للمساعدة على الإنجاب، ولأي أعراض أخرى.قيح للمساعدة على الإنجاب، ولأي أعراض أخرى.
|
| rdfs:label |
Antagonista dell'ormone di rilascio delle gonadotropine
, Gonadotropin-releasing hormone antagonist
, مضاد موجهة الغدد التناسلية
|
