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| http://dbpedia.org/ontology/abstract | Giant-cell fibroma is a type of fibroma no … Giant-cell fibroma is a type of fibroma not associated with trauma or irritation. It can occur at any age and on a mucous membrane surface. The most common oral locations are on the gingiva of the mandible, tongue, and palate. It is a localized reactive proliferation of fibrous connective tissue. Giant-cell fibroma (GCF) is a benign non-neoplastic lesion first described by Weathers and Callihan (1974). It occurs in the first three decades of life and predominates in females (Houston, 1982; Bakos, 1992). Clinically, the GCF presents as an asymptomatic, papillary and pedunculated lesion. The most predominant location is the mandibular gingiva (Houston, 1982; Bakos, 1992). Histologically, the GCF is distinctive, consisting of fibrous connective tissue without inflammation and covered with stratified squamous hyperplastic epithelium. The most characteristic histological feature is the presence of large spindle-shaped and stellate-shaped mononuclear cells and multinucleated cells. These cells occur in a variety of lesions, such as the fibrous papule of the nose, ungual fibroma, acral fibrokeratoma, acral angiofibroma and desmoplastic fibroblastoma (Swan, 1988; Pitt et al., 1993; Karabela-Bouropoulou et al., 1999; Jang et al., 1999). Despite many studies, the nature of the stellated multinucleate and mononuclear cell is not clear (Weathers and Campbell, 1974; Regezi et al., 1987; Odell et al., 1994; Magnusson and Rasmusson, 1995).al., 1994; Magnusson and Rasmusson, 1995). |
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| http://dbpedia.org/ontology/wikiPageID | 7454361 |
| http://dbpedia.org/ontology/wikiPageLength | 2130 |
| http://dbpedia.org/ontology/wikiPageRevisionID | 1060272858 |
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| http://purl.org/dc/terms/subject | http://dbpedia.org/resource/Category:Oral_neoplasia + |
| http://purl.org/linguistics/gold/hypernym | http://dbpedia.org/resource/Fibroma + |
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| rdfs:comment | Giant-cell fibroma is a type of fibroma no … Giant-cell fibroma is a type of fibroma not associated with trauma or irritation. It can occur at any age and on a mucous membrane surface. The most common oral locations are on the gingiva of the mandible, tongue, and palate. It is a localized reactive proliferation of fibrous connective tissue.roliferation of fibrous connective tissue. |
| rdfs:label | Giant-cell fibroma |
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