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A razão eudísmica ou proporção eudísmica é … A razão eudísmica ou proporção eudísmica é a diferença da atividade farmacológica entre os dois enantiômeros de uma droga, tanto in vitro como in vivo. Na maioria dos casos em que um composto quiral é biologicamente ativo, um enantiômero é mais ativo que o outro, de modo que a proporção eudismica é um indicador de enantiosseletividade e de potência farmacológica entre os enântiomêros. Uma razão eudísmica de significância estatística menor que 1 representa que os enântiomeros são diferentes em atividade farmacólogica.são diferentes em atividade farmacólogica.
, Das eudismische Verhältnis ist eine abgele … Das eudismische Verhältnis ist eine abgeleitete Größe aus der medizinischen Chemie, welche für einen chiralen Liganden die Stereoselektivität an einem Protein angibt. Das eudismische Verhältnis ist der Quotient aus der Affinität oder der Aktivität des wirksameren Enantiomers (Eutomer) und der Affinität oder Aktivität des weniger wirksamen Enantiomers (Distomer). Der dekadische Logarithmus des eudismischen Verhältnisses wird auch als eudismischer Index bezeichnet. Eine mögliche Korrelation zwischen der Affinität eines Liganden und seinem eudismischen Verhältnis wird in der Pfeifferschen Regel beschrieben.rd in der Pfeifferschen Regel beschrieben.
, The eudysmic ratio (also spelled eudismic … The eudysmic ratio (also spelled eudismic ratio) represents the difference in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active than the other. The eudysmic ratio is the ratio of activity between the two. A eudysmic ratio significantly differing from 1 means that they are statistically different in activity. Eudisimic ratio (ER) reflects the degree of enantioselectivity of the biological systems..For example, (S)-propranolol (ER = 130) meaning that (S)-propranolol is 130 times as active as its (R )- enantiomer.0 times as active as its (R )- enantiomer.
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The eudysmic ratio (also spelled eudismic … The eudysmic ratio (also spelled eudismic ratio) represents the difference in pharmacologic activity between the two enantiomers of a drug. In most cases where a chiral compound is biologically active, one enantiomer is more active than the other. The eudysmic ratio is the ratio of activity between the two. A eudysmic ratio significantly differing from 1 means that they are statistically different in activity. Eudisimic ratio (ER) reflects the degree of enantioselectivity of the biological systems..For example, (S)-propranolol (ER = 130) meaning that (S)-propranolol is 130 times as active as its (R )- enantiomer.0 times as active as its (R )- enantiomer.
, Das eudismische Verhältnis ist eine abgele … Das eudismische Verhältnis ist eine abgeleitete Größe aus der medizinischen Chemie, welche für einen chiralen Liganden die Stereoselektivität an einem Protein angibt. Das eudismische Verhältnis ist der Quotient aus der Affinität oder der Aktivität des wirksameren Enantiomers (Eutomer) und der Affinität oder Aktivität des weniger wirksamen Enantiomers (Distomer). weniger wirksamen Enantiomers (Distomer).
, A razão eudísmica ou proporção eudísmica é … A razão eudísmica ou proporção eudísmica é a diferença da atividade farmacológica entre os dois enantiômeros de uma droga, tanto in vitro como in vivo. Na maioria dos casos em que um composto quiral é biologicamente ativo, um enantiômero é mais ativo que o outro, de modo que a proporção eudismica é um indicador de enantiosseletividade e de potência farmacológica entre os enântiomêros. Uma razão eudísmica de significância estatística menor que 1 representa que os enântiomeros são diferentes em atividade farmacólogica.são diferentes em atividade farmacólogica.
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Eudismisches Verhältnis
, Razão eudísmica
, Eudysmic ratio
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