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미생물학에서 디스크 확산법(Disk diffusion method) 또는 커 … 미생물학에서 디스크 확산법(Disk diffusion method) 또는 커비-바우어 검사(Kirby-Bauer test)는 세균의 을 측정하는 방법(항생제 감수성 검사)의 하나다. 항생제가 포함된 디스크를 배지에 올려두면 디스크 주위로 항생제 성분이 농도 기울기를 형성하면서 확산한다. 세균이 항생제 감수성을 가질 경우, 항생제 성분이 특정 농도 이상인 부분에서 세균의 생장이 억제되어 고리 모양의 억제 영역을 관찰할 수 있다. 억제 영역의 지름을 측정하여 세균이 항생제에 어느 정도의 감수성을 가지는지 판별할 수 있다. 이 방법을 통해 적은 비용으로 여러 종류의 항생제에 대한 세균의 감수성을 알아낼 수 있다. 적은 비용으로 여러 종류의 항생제에 대한 세균의 감수성을 알아낼 수 있다.
, The disk diffusion test (also known as the … The disk diffusion test (also known as the agar diffusion test, Kirby–Bauer test, disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test and KB test) is a culture-based microbiology assay used in diagnostic and drug discovery laboratories. In diagnostic labs, the assay is used to determine the susceptibility of bacteria isolated from a patient's infection to clinically approved antibiotics. This allows physicians to prescribe the most appropriate antibiotic treatment. In drug discovery labs, especially bioprospecting labs, the assay is used to screen biological material (e.g. plant extracts, bacterial fermentation broths) and drug candidates for antibacterial activity. When bioprospecting, the assay can be performed with paired strains of bacteria to achieve dereplication and provisionally identify antibacterial mechanism of action. In diagnostic laboratories, the test is performed by inoculating the surface of an agar plate with bacteria isolated from a patient's infection. Antibiotic-containing paper disks are then applied to the agar and the plate is incubated. If an antibiotic stops the bacteria from growing or kills the bacteria, there will be an area around the disk where the bacteria have not grown enough to be visible. This is called a zone of inhibition. The susceptibility of the bacterial isolate to each antibiotic can then be semi-quantified by comparing the size of these zones of inhibition to databases of information on known antibiotic-susceptible, moderately susceptible and resistant bacteria. In this way, it is possible to identify the most appropriate antibiotic for treating a patient's infection. Although the disk diffusion test cannot be used to differentiate bacteriostatic and bactericidal activity, it is less cumbersome than other susceptibility test methods such as broth dilution. In drug discovery labs, the disk diffusion test is performed slightly differently than in diagnostic labs. In this setting, it is not the bacterial strain that must be characterized, but a test extract (e.g. a plant or microbial extract). The agar plate is therefore inoculated with a bacterial strain of known phenotype (often an ATCC or NCTC strain), and disks containing the test extract are applied to the surface. Zone of inhibition sizes cannot be used as a semi-quantitative measure of antibacterial potency because different extracts contain molecules with different diffusion characteristics (different molecular sizes, hydrophilicities etc.). Zone of inhibition sizes can be used for the purpose of dereplication though. This is achieved by testing each extract against paired strains of bacteria (e.g. streptomycin-susceptible and -resistant strains to identify streptomycin-containing extracts). Paired strains (e.g. wild type and target overexpressing strains) can also be used to identify antibacterial mechanism of action.dentify antibacterial mechanism of action.
, Agardiffusionstest ist ein Oberbegriff für … Agardiffusionstest ist ein Oberbegriff für immunologische und mikrobiologische Verfahren, bei denen sich die zu untersuchenden biologische Reagenzien in einem Agarmedium durch Diffusion ausbreiten.
* Bei der Untersuchung von Antigenen mit Antikörpern wird der Immundiffusionstest angewendet (siehe auch Immunelektrophorese).
* Bei der Untersuchung von auf Mikroorganismen wachstumshemmend (Hemmstoffe wie Antibiotika) oder wachstumsfördernd (Vitamine, Aminosäuren) wirkenden Verbindungen findet der Plattendiffusionstest Anwendung. Eine Spezialanwendung des Plattendiffusionstests ist der Hemmhoftest.lattendiffusionstests ist der Hemmhoftest.
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The disk diffusion test (also known as the … The disk diffusion test (also known as the agar diffusion test, Kirby–Bauer test, disc-diffusion antibiotic susceptibility test, disc-diffusion antibiotic sensitivity test and KB test) is a culture-based microbiology assay used in diagnostic and drug discovery laboratories. In diagnostic labs, the assay is used to determine the susceptibility of bacteria isolated from a patient's infection to clinically approved antibiotics. This allows physicians to prescribe the most appropriate antibiotic treatment. In drug discovery labs, especially bioprospecting labs, the assay is used to screen biological material (e.g. plant extracts, bacterial fermentation broths) and drug candidates for antibacterial activity. When bioprospecting, the assay can be performed with paired strains of bacteria to achied with paired strains of bacteria to achi
, Agardiffusionstest ist ein Oberbegriff für … Agardiffusionstest ist ein Oberbegriff für immunologische und mikrobiologische Verfahren, bei denen sich die zu untersuchenden biologische Reagenzien in einem Agarmedium durch Diffusion ausbreiten.
* Bei der Untersuchung von Antigenen mit Antikörpern wird der Immundiffusionstest angewendet (siehe auch Immunelektrophorese).
* Bei der Untersuchung von auf Mikroorganismen wachstumshemmend (Hemmstoffe wie Antibiotika) oder wachstumsfördernd (Vitamine, Aminosäuren) wirkenden Verbindungen findet der Plattendiffusionstest Anwendung. Eine Spezialanwendung des Plattendiffusionstests ist der Hemmhoftest.lattendiffusionstests ist der Hemmhoftest.
, 미생물학에서 디스크 확산법(Disk diffusion method) 또는 커 … 미생물학에서 디스크 확산법(Disk diffusion method) 또는 커비-바우어 검사(Kirby-Bauer test)는 세균의 을 측정하는 방법(항생제 감수성 검사)의 하나다. 항생제가 포함된 디스크를 배지에 올려두면 디스크 주위로 항생제 성분이 농도 기울기를 형성하면서 확산한다. 세균이 항생제 감수성을 가질 경우, 항생제 성분이 특정 농도 이상인 부분에서 세균의 생장이 억제되어 고리 모양의 억제 영역을 관찰할 수 있다. 억제 영역의 지름을 측정하여 세균이 항생제에 어느 정도의 감수성을 가지는지 판별할 수 있다. 이 방법을 통해 적은 비용으로 여러 종류의 항생제에 대한 세균의 감수성을 알아낼 수 있다. 적은 비용으로 여러 종류의 항생제에 대한 세균의 감수성을 알아낼 수 있다.
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| rdfs:label |
Agardiffusionstest
, 디스크 확산 검사
, Disk diffusion test
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