| http://dbpedia.org/ontology/abstract
|
Die Cystathionin-β-Lyase (CBL) ist ein Enzym aus der Gruppe der Lyasen, dass an der Übertragung von schwefelhaltigen Molekülen im Aminosäurestoffwechsel beteiligt ist.
, Cystathionine beta-lyase (EC 4.4.1.8), als … Cystathionine beta-lyase (EC 4.4.1.8), also commonly referred to as CBL or β-cystathionase, is an enzyme that primarily catalyzes the following α,β-elimination reaction Thus, the substrate of this enzyme is L-cystathionine, whereas its 3 products are homocysteine, pyruvate, and ammonia. Found in plants, bacteria, and yeast, cystathionine beta-lyase is an essential part of the methionine biosynthesis pathway as homocysteine can be directly converted into methionine by methionine synthase. The enzyme belongs to the γ-family of PLP-dependent enzymes due to its use of a pyridoxal-5'-phosphate (PLP) cofactor to cleave cystathionine. The enzyme also belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming). This enzyme participates in 5 metabolic pathways: methionine metabolism, cysteine metabolism, , nitrogen metabolism, and sulfur metabolism.itrogen metabolism, and sulfur metabolism.
|
| http://dbpedia.org/ontology/ecNumber
|
4.4.1.8
|
| http://dbpedia.org/ontology/thumbnail
|
http://commons.wikimedia.org/wiki/Special:FilePath/4itx.jpg?width=300 +
|
| http://dbpedia.org/ontology/wikiPageID
|
14221532
|
| http://dbpedia.org/ontology/wikiPageLength
|
18988
|
| http://dbpedia.org/ontology/wikiPageRevisionID
|
1057950966
|
| http://dbpedia.org/ontology/wikiPageWikiLink
|
http://dbpedia.org/resource/Biosynthesis +
, http://dbpedia.org/resource/Antiparallel_%28biochemistry%29 +
, http://dbpedia.org/resource/Nitrogen_metabolism +
, http://dbpedia.org/resource/Hydrolysis +
, http://dbpedia.org/resource/Chemical_bond +
, http://dbpedia.org/resource/Molecular_symmetry +
, http://dbpedia.org/resource/Antimicrobial +
, http://dbpedia.org/resource/Enamine +
, http://dbpedia.org/resource/Tyrosine +
, http://dbpedia.org/resource/Cystathionine +
, http://dbpedia.org/resource/Phenol +
, http://dbpedia.org/resource/Pyridoxal_phosphate +
, http://dbpedia.org/resource/File:PLP_in_binding_pocket.png +
, http://dbpedia.org/resource/Pyridine +
, http://dbpedia.org/resource/File:Plant_CBL_Inhibition.png +
, http://dbpedia.org/resource/Amino_acid +
, http://dbpedia.org/resource/File:Cystathionine_Beta-Lyase_Catalyzed_Reaction.png +
, http://dbpedia.org/resource/Enzyme +
, http://dbpedia.org/resource/File:Cystathionine_beta-lyase_dimer.gif +
, http://dbpedia.org/resource/File:Bacterial_CBL_Inhibition.png +
, http://dbpedia.org/resource/File:CBL_PLP-dependent_mechanism.png +
, http://dbpedia.org/resource/Selenoamino_acid_metabolism +
, http://dbpedia.org/resource/File:AVG_bounded_PLP.png +
, http://dbpedia.org/resource/Tautomer +
, http://dbpedia.org/resource/Hydrogen_bond +
, http://dbpedia.org/resource/Methionine_metabolism +
, http://dbpedia.org/resource/Protein_quaternary_structure +
, http://dbpedia.org/resource/Category:Pyridoxal_phosphate_enzymes +
, http://dbpedia.org/resource/PH +
, http://dbpedia.org/resource/Metabolism +
, http://dbpedia.org/resource/Cys/Met_metabolism_PLP-dependent_enzyme_family +
, http://dbpedia.org/resource/Methionine_synthase +
, http://dbpedia.org/resource/Alpha_helix +
, http://dbpedia.org/resource/Cysteine_metabolism +
, http://dbpedia.org/resource/Beta_sheet +
, http://dbpedia.org/resource/Dehydroalanine +
, http://dbpedia.org/resource/Monomer +
, http://dbpedia.org/resource/Dimer_%28chemistry%29 +
, http://dbpedia.org/resource/Hydroxy_group +
, http://dbpedia.org/resource/Reaction_intermediate +
, http://dbpedia.org/resource/Lysine +
, http://dbpedia.org/resource/Cofactor_%28biochemistry%29 +
, http://dbpedia.org/resource/Cystathionine_gamma-lyase +
, http://dbpedia.org/resource/Reaction_mechanism +
, http://dbpedia.org/resource/Protein_subunit +
, http://dbpedia.org/resource/Cystathionine_gamma-synthase +
, http://dbpedia.org/resource/Category:EC_4.4.1 +
, http://dbpedia.org/resource/Aspartate_transaminase +
, http://dbpedia.org/resource/Antibiotics +
, http://dbpedia.org/resource/Plant +
, http://dbpedia.org/resource/Escherichia_coli +
, http://dbpedia.org/resource/Molecule +
, http://dbpedia.org/resource/List_of_enzymes +
, http://dbpedia.org/resource/Arabidopsis +
, http://dbpedia.org/resource/Competitive_inhibition +
, http://dbpedia.org/resource/N-terminus +
, http://dbpedia.org/resource/Methionine_gamma-lyase +
, http://dbpedia.org/resource/Coplanarity +
, http://dbpedia.org/resource/Deamination +
, http://dbpedia.org/resource/Transsulfuration_pathway +
, http://dbpedia.org/resource/Hydrophobic_interactions +
, http://dbpedia.org/resource/C-terminus +
, http://dbpedia.org/resource/Amine +
, http://dbpedia.org/resource/Category:Enzymes_of_known_structure +
, http://dbpedia.org/resource/Homology_%28biology%29 +
, http://dbpedia.org/resource/DNA +
, http://dbpedia.org/resource/Yeast +
, http://dbpedia.org/resource/Iodoacetamide +
, http://dbpedia.org/resource/Sulfur_metabolism +
, http://dbpedia.org/resource/Delocalized_electron +
, http://dbpedia.org/resource/Tetramer +
, http://dbpedia.org/resource/Ammonia +
, http://dbpedia.org/resource/Chemical_reaction +
, http://dbpedia.org/resource/Substrate_%28chemistry%29 +
, http://dbpedia.org/resource/Nucleophile +
, http://dbpedia.org/resource/Nitrogen +
, http://dbpedia.org/resource/Oxygen +
, http://dbpedia.org/resource/DNA_replication +
, http://dbpedia.org/resource/Lyase +
, http://dbpedia.org/resource/Aromaticity +
, http://dbpedia.org/resource/X-ray_crystallography +
, http://dbpedia.org/resource/Chemical_kinetics +
, http://dbpedia.org/resource/Catalysis +
, http://dbpedia.org/resource/Product_%28chemistry%29 +
, http://dbpedia.org/resource/Phosphate +
, http://dbpedia.org/resource/Metabolic_pathway +
, http://dbpedia.org/resource/Side_effect +
, http://dbpedia.org/resource/Active_site +
, http://dbpedia.org/resource/Side_chain +
, http://dbpedia.org/resource/Methionine +
, http://dbpedia.org/resource/N-Ethylmaleimide +
, http://dbpedia.org/resource/Conjugated_system +
, http://dbpedia.org/resource/Schiff_base +
, http://dbpedia.org/resource/Aldimine +
, http://dbpedia.org/resource/Electron +
, http://dbpedia.org/resource/Pyruvic_acid +
, http://dbpedia.org/resource/Deprotonation +
, http://dbpedia.org/resource/Thiol +
, http://dbpedia.org/resource/Saccharomyces_cerevisiae +
, http://dbpedia.org/resource/Electric_charge +
, http://dbpedia.org/resource/Electrostatics +
, http://dbpedia.org/resource/Electrophile +
, http://dbpedia.org/resource/Homocysteine +
, http://dbpedia.org/resource/Imine +
, http://dbpedia.org/resource/Bacteria +
, http://dbpedia.org/resource/S-Adenosyl_methionine +
|
| http://dbpedia.org/property/caption
|
Cystathionine beta-lyase tetramer, E.Coli
|
| http://dbpedia.org/property/casNumber
|
"9055-05-04"^^xsd:date
|
| http://dbpedia.org/property/ecNumber
|
4.4
|
| http://dbpedia.org/property/goCode
|
4121
|
| http://dbpedia.org/property/iubmbEcNumber
|
4
|
| http://dbpedia.org/property/name
|
cystathionine beta-lyase
|
| http://dbpedia.org/property/width
|
270
|
| http://dbpedia.org/property/wikiPageUsesTemplate
|
http://dbpedia.org/resource/Template:Reflist +
, http://dbpedia.org/resource/Template:Portal_bar +
, http://dbpedia.org/resource/Template:Enzymes +
, http://dbpedia.org/resource/Template:EC_number +
, http://dbpedia.org/resource/Template:Carbon-sulfur_lyases +
, http://dbpedia.org/resource/Template:Enzyme +
|
| http://purl.org/dc/terms/subject
|
http://dbpedia.org/resource/Category:Pyridoxal_phosphate_enzymes +
, http://dbpedia.org/resource/Category:EC_4.4.1 +
, http://dbpedia.org/resource/Category:Enzymes_of_known_structure +
|
| http://www.w3.org/ns/prov#wasDerivedFrom
|
http://en.wikipedia.org/wiki/Cystathionine_beta-lyase?oldid=1057950966&ns=0 +
|
| http://xmlns.com/foaf/0.1/depiction
|
http://commons.wikimedia.org/wiki/Special:FilePath/PLP_in_binding_pocket.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/AVG_bounded_PLP.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/4itx.jpg +
, http://commons.wikimedia.org/wiki/Special:FilePath/Cystathionine_Beta-Lyase_Catalyzed_Reaction.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/Cystathionine_beta-lyase_dimer.gif +
, http://commons.wikimedia.org/wiki/Special:FilePath/Plant_CBL_Inhibition.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/Bacterial_CBL_Inhibition.png +
, http://commons.wikimedia.org/wiki/Special:FilePath/CBL_PLP-dependent_mechanism.png +
|
| http://xmlns.com/foaf/0.1/isPrimaryTopicOf
|
http://en.wikipedia.org/wiki/Cystathionine_beta-lyase +
|
| http://xmlns.com/foaf/0.1/name
|
cystathionine beta-lyase
|
| owl:sameAs |
http://yago-knowledge.org/resource/Cystathionine_beta-lyase +
, https://global.dbpedia.org/id/4j2RW +
, http://sr.dbpedia.org/resource/Cistationinska_b-lijaza +
, http://de.dbpedia.org/resource/Cystathionin-%CE%B2-Lyase +
, http://www.wikidata.org/entity/Q5201180 +
, http://sh.dbpedia.org/resource/Cistationinska_b-lijaza +
, http://fa.dbpedia.org/resource/%D8%B3%DB%8C%D8%B3%D8%AA%D8%A7%D8%AA%DB%8C%D9%88%D9%86%DB%8C%D9%86_%D8%A8%D8%AA%D8%A7_%D9%84%DB%8C%D8%A7%D8%B2 +
, http://rdf.freebase.com/ns/m.03cy73x +
, http://dbpedia.org/resource/Cystathionine_beta-lyase +
|
| rdf:type |
http://dbpedia.org/ontology/Enzyme +
, http://dbpedia.org/class/yago/Activator114723079 +
, http://dbpedia.org/class/yago/Enzyme114732946 +
, http://dbpedia.org/class/yago/Catalyst114723628 +
, http://dbpedia.org/ontology/Biomolecule +
, http://dbpedia.org/class/yago/WikicatPyridoxalPhosphateEnzymes +
, http://dbpedia.org/class/yago/Relation100031921 +
, http://dbpedia.org/class/yago/Abstraction100002137 +
, http://dbpedia.org/class/yago/Macromolecule114944888 +
, http://dbpedia.org/class/yago/Matter100020827 +
, http://dbpedia.org/class/yago/Protein114728724 +
, http://dbpedia.org/class/yago/OrganicCompound114727670 +
, http://dbpedia.org/class/yago/Material114580897 +
, http://dbpedia.org/class/yago/Compound114818238 +
, http://dbpedia.org/class/yago/Chemical114806838 +
, http://dbpedia.org/class/yago/Substance100019613 +
, http://dbpedia.org/class/yago/Thing100002452 +
, http://dbpedia.org/class/yago/Molecule114682133 +
, http://www.wikidata.org/entity/Q8047 +
, http://dbpedia.org/class/yago/Unit109465459 +
, http://dbpedia.org/class/yago/WikicatEnzymesOfKnownStructure +
, http://www.wikidata.org/entity/Q206229 +
, http://dbpedia.org/class/yago/Part113809207 +
, http://dbpedia.org/class/yago/PhysicalEntity100001930 +
|
| rdfs:comment |
Die Cystathionin-β-Lyase (CBL) ist ein Enzym aus der Gruppe der Lyasen, dass an der Übertragung von schwefelhaltigen Molekülen im Aminosäurestoffwechsel beteiligt ist.
, Cystathionine beta-lyase (EC 4.4.1.8), als … Cystathionine beta-lyase (EC 4.4.1.8), also commonly referred to as CBL or β-cystathionase, is an enzyme that primarily catalyzes the following α,β-elimination reaction Thus, the substrate of this enzyme is L-cystathionine, whereas its 3 products are homocysteine, pyruvate, and ammonia.s are homocysteine, pyruvate, and ammonia.
|
| rdfs:label |
Cystathionin-β-Lyase
, Cystathionine beta-lyase
|
