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Corydaline ies un inhibidor de la acetilcolinesterasa aislado de la planta Corydalis yanhusuo.
, Corydaline is an acetylcholinesterase inhi … Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo. Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities. Corydaline exhibited strong nematocidal activity, showed little cytotoxicity and represents a potential treatment for Strongyloidiasis. Corydaline is nematocidal against S. ratti and S. venezuelensis third instar larvae with 50% paralysis (PC50) values of 18 and 30 μM, respectively. Corydaline exhibits gastrointestinal modulatory, antinociceptive, anti-allergic, and anti-parasitic activities. Corydaline (1 and 3 mg/kg) increases gastric emptying in rat models of apomorphine- and laparotomy-induced delayed gastric emptying. Corydaline is currently in clinical trials as a potential treatment for functional dyspepsia. In animal models, corydaline increases gastric emptying and small intestine transit speed and induces gastric relaxation. In other animal models, corydaline inhibits chemically-induced pain. Additionally, this compound may inhibit mast cell-dependent smooth muscle contraction of the aorta. It inhibits thrombin-induced platelet aggregation in vitro (IC50 = 54.16 μg/ml).aggregation in vitro (IC50 = 54.16 μg/ml).
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(13S,13aR)-2,3,9,10-Tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline
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| rdfs:comment |
Corydaline ies un inhibidor de la acetilcolinesterasa aislado de la planta Corydalis yanhusuo.
, Corydaline is an acetylcholinesterase inhi … Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo. Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities. In animal models, corydaline increases gastric emptying and small intestine transit speed and induces gastric relaxation. It inhibits thrombin-induced platelet aggregation in vitro (IC50 = 54.16 μg/ml).aggregation in vitro (IC50 = 54.16 μg/ml).
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| rdfs:label |
Corydalina
, Corydaline
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