| http://dbpedia.org/ontology/abstract
|
Conantokins are a small family of helical … Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus Conus. Conantokins act as potent and specific antagonists of the N-methyl-D-aspartate receptor (NMDAR). They are the only naturally-derived peptides to do so. The subtypes of conantokins exhibit a surprising variability of selectivity across the NMDAR subunits, and are therefore uniquely useful in developing subunit-specific pharmacological probes. Chemically, conantokins are unique in that they possess a number (generally 4 or 5) of gamma-carboxyglutamyl (Gla) residues, generated by the post-translational modification of glutamyl (Glu) residues. These Gla residues induce a conformational change from a 3 10 helix to an alpha helix on binding to Calcium. In the broader scheme of genetic conotoxin classification, Conanotokins are also known as "Conotoxin Superfamily B." The word "conantokin" is derived from the Filipino word antokin, meaning sleepy.the Filipino word antokin, meaning sleepy.
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Conantokin
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|
http://biology.burke.washington.edu/conus/%7C +
, http://www.conoserver.org/ +
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33438445
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16610
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1051481383
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http://dbpedia.org/resource/Conus_sulcatus +
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IPR005918
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| http://dbpedia.org/property/name
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Conantokin
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| http://dbpedia.org/property/pfam
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PF10550
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| http://dbpedia.org/property/prosite
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PS60025
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1
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Conantokin
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|
| rdfs:comment |
Conantokins are a small family of helical … Conantokins are a small family of helical peptides that are derived from the venom of predatory marine snails of the genus Conus. Conantokins act as potent and specific antagonists of the N-methyl-D-aspartate receptor (NMDAR). They are the only naturally-derived peptides to do so. The subtypes of conantokins exhibit a surprising variability of selectivity across the NMDAR subunits, and are therefore uniquely useful in developing subunit-specific pharmacological probes. The word "conantokin" is derived from the Filipino word antokin, meaning sleepy.the Filipino word antokin, meaning sleepy.
|
| rdfs:label |
Conantokin
|
