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Ced-3 is one of the major protein componen … Ced-3 is one of the major protein components of the programmed cell death (PCD) pathway for Caenorhabditis elegans. There are in total 14 genes that are involved in programmed cell death, other important ones including ced-4 and ced-9 genes. The healthy nematode worm will require 131 somatic cell deaths out of the 1090 cells during the developmental stages. The gene initially encodes for a prototypical caspase (procaspase) where the active cysteine residue cleaves aspartate residues, thus becoming a functional caspase. Ced-3 is an executioner caspase (cysteine-dependent aspartate-directed protease) that must dimerize with itself and be initiated by ced-4 in order to become active. Once active, it will have a series of reactions that will ultimately lead to the apoptosis of targeted cells. Programmed cell death in C. elegans will occur in the embryonic and post-embryonic stages in both somatic and germ line cells. During embryogenesis is when the ced-3 transcript is at its highest peak due to the numerous cells that need to undergo cell suicide. Most programmed cell deaths occur in the brain tissue of the C. elegans where the majority of cells targeted for cell death have lineages from neuronal and glial cells. From there, ced-3 is localized to perinuclear regions of the cells. In order for ced-3 to become functional, it requires auto-catalytic cleavage which is initiated by ced-4, acting as an initiator caspase. Ced-3 gene is found downstream of ced-4 and positively regulates ced-3. It can also be indirectly inhibited by ced-9 and prevent apoptosis by inhibiting the function of ced-4 thus inhibiting the function of ced-3. The ced-3 ortholog in humans is caspase 9, an interleukin-1β converting enzyme (ICE) and the ortholog in mice was found to be the Nedd-2 gene.g in mice was found to be the Nedd-2 gene.
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| rdfs:comment |
Ced-3 is one of the major protein componen … Ced-3 is one of the major protein components of the programmed cell death (PCD) pathway for Caenorhabditis elegans. There are in total 14 genes that are involved in programmed cell death, other important ones including ced-4 and ced-9 genes. The healthy nematode worm will require 131 somatic cell deaths out of the 1090 cells during the developmental stages. The gene initially encodes for a prototypical caspase (procaspase) where the active cysteine residue cleaves aspartate residues, thus becoming a functional caspase. Ced-3 is an executioner caspase (cysteine-dependent aspartate-directed protease) that must dimerize with itself and be initiated by ced-4 in order to become active. Once active, it will have a series of reactions that will ultimately lead to the apoptosis of targeted cells.y lead to the apoptosis of targeted cells.
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Ced-3
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