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La Catepsina D è una proteina che nell'uom … La Catepsina D è una proteina che nell'uomo viene codificata dal gene CTSD localizzato sul cromosoma 11, 1.73 - 1.74 Mb umano e sul cromosoma 7, 142.19 - 142.2 Mb murino . Struttura proteica della Catepsina D, tale struttura è composta da due dimeri.Pattern di espressione del gene CTSDPattern di espressione del gene CTSD Questo gene codifica per una aspartil-proteasi lisosomiale composta da un dimero di catene pesanti e leggere legate da ponti disolfuro, entrambi i dimeri vengono prodotti da una singola proteina precursore. Questa proteasi, è un membro della famiglia delle peptidasi C1, possiede una specificità simile ma maggiormente ristretta rispetto alla pepsina A. La trascrizione di questo gene viene attivata da diversi siti, tra cui uno è un sito di partenza per una trascrizione regolata dagli estrogeni. Mutazioni in questo gene portano all'insorgenza di diverse malattie, compreso il cancro al seno e, eventualmente, la malattia di Alzheimer. CTSD viene impiegato come marcatore tumorale del cancro della mammella . Catepsina-D è un aspartil-proteasi la cui attività metabolica dipende strettamente dalla protonazione dei suoi siti attivi posti a livello del residuo Asp e viene attivata a pH 5 negli epatociti dove svolge la funzione di degradazione dell'insulina .a funzione di degradazione dell'insulina .
, Cathepsin D is a protein that in humans is … Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase. Deficiency of CTSD gene has been reported an underlying cause of neuronal ceroid lipofuscinosis (NCL).e of neuronal ceroid lipofuscinosis (NCL).
, 组织蛋白酶D是一种在人体中由CTSD基因编码的蛋白质。该基因编码一种溶酶体天冬氨酰蛋 … 组织蛋白酶D是一种在人体中由CTSD基因编码的蛋白质。该基因编码一种溶酶体天冬氨酰蛋白酶，该蛋白酶由二硫键连接的重链和轻链的蛋白二聚体组成，两者均由单一蛋白质前体产生。组织蛋白酶D是一种天冬氨酸内切蛋白酶，广泛分布于溶酶体中。组织蛋白酶D的主要功能是降解蛋白质并激活溶酶体前区室中生物活性蛋白的前体。这种蛋白酶是肽酶A1家族的成员，具有与胃蛋白酶A相似但比胃蛋白酶A更窄的特异性。 CTSD基因的转录从几个位点开始，包括一个作为雌激素调节转录物起始位点的位点。该基因的突变与几种疾病的发病机制有关，包括乳腺癌和可能的阿尔茨海默病症。CTSD基因的纯合缺失导致出生后阶段的早期致死性。据报道，CTSD基因的缺陷是（NCL）的根本原因。合缺失导致出生后阶段的早期致死性。据报道，CTSD基因的缺陷是（NCL）的根本原因。
, Катепсин D (англ. Cathepsin D) – білок, як … Катепсин D (англ. Cathepsin D) – білок, який кодується геном CTSD, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 412 амінокислот, а молекулярна маса — 44 552. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Цей білок за функціями належить до гідролаз, протеаз, . Локалізований у лізосомі.Також секретований назовні.ний у лізосомі.Також секретований назовні.
, La cathepsine D est une protéine appartenant à la famille des cathepsines et qui est encodée par le gène CTSD situé sur le chromosome 11 chez l'humain.
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| rdfs:comment |
La Catepsina D è una proteina che nell'uom … La Catepsina D è una proteina che nell'uomo viene codificata dal gene CTSD localizzato sul cromosoma 11, 1.73 - 1.74 Mb umano e sul cromosoma 7, 142.19 - 142.2 Mb murino . Struttura proteica della Catepsina D, tale struttura è composta da due dimeri.Pattern di espressione del gene CTSDPattern di espressione del gene CTSD CTSD viene impiegato come marcatore tumorale del cancro della mammella .atore tumorale del cancro della mammella .
, 组织蛋白酶D是一种在人体中由CTSD基因编码的蛋白质。该基因编码一种溶酶体天冬氨酰蛋 … 组织蛋白酶D是一种在人体中由CTSD基因编码的蛋白质。该基因编码一种溶酶体天冬氨酰蛋白酶，该蛋白酶由二硫键连接的重链和轻链的蛋白二聚体组成，两者均由单一蛋白质前体产生。组织蛋白酶D是一种天冬氨酸内切蛋白酶，广泛分布于溶酶体中。组织蛋白酶D的主要功能是降解蛋白质并激活溶酶体前区室中生物活性蛋白的前体。这种蛋白酶是肽酶A1家族的成员，具有与胃蛋白酶A相似但比胃蛋白酶A更窄的特异性。 CTSD基因的转录从几个位点开始，包括一个作为雌激素调节转录物起始位点的位点。该基因的突变与几种疾病的发病机制有关，包括乳腺癌和可能的阿尔茨海默病症。CTSD基因的纯合缺失导致出生后阶段的早期致死性。据报道，CTSD基因的缺陷是（NCL）的根本原因。合缺失导致出生后阶段的早期致死性。据报道，CTSD基因的缺陷是（NCL）的根本原因。
, Катепсин D (англ. Cathepsin D) – білок, як … Катепсин D (англ. Cathepsin D) – білок, який кодується геном CTSD, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 412 амінокислот, а молекулярна маса — 44 552. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Цей білок за функціями належить до гідролаз, протеаз, . Локалізований у лізосомі.Також секретований назовні.ний у лізосомі.Також секретований назовні.
, Cathepsin D is a protein that in humans is … Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments. This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, iin the pathogenesis of several diseases, i
, La cathepsine D est une protéine appartenant à la famille des cathepsines et qui est encodée par le gène CTSD situé sur le chromosome 11 chez l'humain.
|
| rdfs:label |
Catepsina D
, Cathepsin D
, Катепсин D
, Cathepsine D
, 组织蛋白酶D
|
