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Aromatische-L-Aminosäure-Decarboxylase (AA … Aromatische-L-Aminosäure-Decarboxylase (AADC), auch DOPA-Decarboxylase (DDC) genannt, ist der Name für Enzyme in Chordatieren, die die Biosynthese von Dopamin, Serotonin und Tryptamin mittels Decarboxylierung katalysieren. Als Entdecker gilt der deutsche Pharmakologe Peter Holtz. Mutationen am entsprechenden DDC-Gen und folgender Mangel am Enzym führen zu Mangel an den entsprechenden Neurotransmittern und Katecholaminen. AADC ist gentherapeutisches Target für die Behandlung der Parkinson-Krankheit; Phase I-Studien wurden 2008 erfolgreich abgeschlossen. Patienten mit polyendokriner Autoimmunerkrankung Typ I (APS1) zeigen zum Teil Autoantikörper auf AADC. Manche Varianten der AADC sind assoziiert mit Nikotinabhängigkeit.C sind assoziiert mit Nikotinabhängigkeit.
, Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase, is a lyase enzyme (EC 4.1.1.28), located in region 7p12.2-p12.1.
, L-Aminoácido aromático descarboxilase (abr … L-Aminoácido aromático descarboxilase (abreviada na literatura AADC ou AAAD do inglês aromatic L-amino acid decarboxylase), também conhecido como DOPA decarboxilase (DDC), triptofano decarboxilase, e 5-hidroxitriptofano decarboxilase, é uma enzima liase. (EC 4.1.1.28)oxilase, é uma enzima liase. (EC 4.1.1.28)
, L-Amminoacidi-Aromatici Decarbossilasi (EC … L-Amminoacidi-Aromatici Decarbossilasi (EC 4.1.1.28; Sinonimi: DOPA decarbossilasi, DDC, L-Dopa decarbossilasi, triptofano decarbossilasi, 5-idrossitriptofano-decarbossilasi, Decarbossilasi degli amminoacidi aromatici, AAAD, AADC) è un enzima liasi presente nel tessuto cerebrale.È implicato in due vie metaboliche, e sintetizza due importanti neurotrasmettitori, la dopamina e la serotonina. Per fare questo, l'enzima DDC rimuove un gruppo carbossilico (Decarbossilazione).n gruppo carbossilico (Decarbossilazione).
, نازعة كربوكسيل L-الحمض الأميني العطري (AADC) المعروفة كذلك باسم نازعة كربوكسيل دوبا (DDC)، نازعة كربوكسيل التريبتوفان و5-هيدروكسي تريبتوفان نازعة الكربوكسيل. هو إنزيم لياز يشفر لدى البشر بواسطة الجين DDC المتواجد على الصبغي 7.
, L'acide L-aminé aromatique décarboxylase e … L'acide L-aminé aromatique décarboxylase est une lyase, également appelée DOPA décarboxylase, tryptophane décarboxylase, 5-hydroxytryptophane décarboxylase - ou encore AADC ou AAAD (de l'anglais Aromatic L-amino acid decarboxylase), qui catalyse plusieurs réactions de décarboxylation : L-DOPA dopamine + CO25-hydroxy-L-tryptophane sérotonine + CO2Tryptophane tryptamine + CO2 Elle agit également sur d'autres acides L-aminés aromatiques. Le phosphate de pyridoxal, forme active de la vitamine B6, intervient comme cofacteur.a vitamine B6, intervient comme cofacteur.
, La L-aminoácido aromático descarboxilasa (sinónimos: DOPA descarboxilasa, triptófano descarboxilasa, 5-Hidroxitriptófano descarboxilasa, AAAD) es una enzima liasa.
, 芳香族L-氨基酸脱羧酶（英語：Aromatic L-amino acid decarboxylase，EC 4.1.1.28；同义词：多巴脱羧酶、色氨酸脱羧酶、5-羟色氨酸脱羧酶、AAAD）是一个裂合酶。
, Dekarboksylaza aromatycznych L-aminokwasów (EC 4.1.1.28) jest enzymem z klasy liaz. Konkretniej, jest , która przeprowadza reakcję dekarboksylacji aromatycznych L-aminokwasów.
, Декарбоксилаза ароматических аминокислот ( … Декарбоксилаза ароматических аминокислот (англ. Aromatic L-amino acid decarboxylase, синонимы: англ. DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) — фермент (энзим), участвующий в процессе органического декарбоксилирования.роцессе органического декарбоксилирования.
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, Aromatic L-amino acid decarboxylase homodimer, Human
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| rdfs:comment |
Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase, is a lyase enzyme (EC 4.1.1.28), located in region 7p12.2-p12.1.
, L'acide L-aminé aromatique décarboxylase e … L'acide L-aminé aromatique décarboxylase est une lyase, également appelée DOPA décarboxylase, tryptophane décarboxylase, 5-hydroxytryptophane décarboxylase - ou encore AADC ou AAAD (de l'anglais Aromatic L-amino acid decarboxylase), qui catalyse plusieurs réactions de décarboxylation : L-DOPA dopamine + CO25-hydroxy-L-tryptophane sérotonine + CO2Tryptophane tryptamine + CO2 Elle agit également sur d'autres acides L-aminés aromatiques. Le phosphate de pyridoxal, forme active de la vitamine B6, intervient comme cofacteur.a vitamine B6, intervient comme cofacteur.
, La L-aminoácido aromático descarboxilasa (sinónimos: DOPA descarboxilasa, triptófano descarboxilasa, 5-Hidroxitriptófano descarboxilasa, AAAD) es una enzima liasa.
, نازعة كربوكسيل L-الحمض الأميني العطري (AADC) المعروفة كذلك باسم نازعة كربوكسيل دوبا (DDC)، نازعة كربوكسيل التريبتوفان و5-هيدروكسي تريبتوفان نازعة الكربوكسيل. هو إنزيم لياز يشفر لدى البشر بواسطة الجين DDC المتواجد على الصبغي 7.
, 芳香族L-氨基酸脱羧酶（英語：Aromatic L-amino acid decarboxylase，EC 4.1.1.28；同义词：多巴脱羧酶、色氨酸脱羧酶、5-羟色氨酸脱羧酶、AAAD）是一个裂合酶。
, L-Aminoácido aromático descarboxilase (abr … L-Aminoácido aromático descarboxilase (abreviada na literatura AADC ou AAAD do inglês aromatic L-amino acid decarboxylase), também conhecido como DOPA decarboxilase (DDC), triptofano decarboxilase, e 5-hidroxitriptofano decarboxilase, é uma enzima liase. (EC 4.1.1.28)oxilase, é uma enzima liase. (EC 4.1.1.28)
, L-Amminoacidi-Aromatici Decarbossilasi (EC … L-Amminoacidi-Aromatici Decarbossilasi (EC 4.1.1.28; Sinonimi: DOPA decarbossilasi, DDC, L-Dopa decarbossilasi, triptofano decarbossilasi, 5-idrossitriptofano-decarbossilasi, Decarbossilasi degli amminoacidi aromatici, AAAD, AADC) è un enzima liasi presente nel tessuto cerebrale.È implicato in due vie metaboliche, e sintetizza due importanti neurotrasmettitori, la dopamina e la serotonina. Per fare questo, l'enzima DDC rimuove un gruppo carbossilico (Decarbossilazione).n gruppo carbossilico (Decarbossilazione).
, Dekarboksylaza aromatycznych L-aminokwasów (EC 4.1.1.28) jest enzymem z klasy liaz. Konkretniej, jest , która przeprowadza reakcję dekarboksylacji aromatycznych L-aminokwasów.
, Aromatische-L-Aminosäure-Decarboxylase (AA … Aromatische-L-Aminosäure-Decarboxylase (AADC), auch DOPA-Decarboxylase (DDC) genannt, ist der Name für Enzyme in Chordatieren, die die Biosynthese von Dopamin, Serotonin und Tryptamin mittels Decarboxylierung katalysieren. Als Entdecker gilt der deutsche Pharmakologe Peter Holtz.ilt der deutsche Pharmakologe Peter Holtz.
, Декарбоксилаза ароматических аминокислот ( … Декарбоксилаза ароматических аминокислот (англ. Aromatic L-amino acid decarboxylase, синонимы: англ. DOPA decarboxylase, tryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, AAAD) — фермент (энзим), участвующий в процессе органического декарбоксилирования.роцессе органического декарбоксилирования.
|
| rdfs:label |
Dekarboksylaza aromatycznych L-aminokwasów
, L-Aminoácido aromático descarboxilase
, L-Aminoácido aromático descarboxilasa
, 芳香族L-氨基酸脱羧酶
, Acide L-aminé aromatique décarboxylase
, نازعة كربوكسيل L-الحمض الأميني العطري
, Декарбоксилаза ароматических аминокислот
, L-Aminoacidi-Aromatici Decarbossilasi
, Aromatische-L-Aminosäure-Decarboxylase
, Aromatic L-amino acid decarboxylase
|
