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Adrenorphin, also sometimes referred to as … Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2, YGGFMRRV-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain. It was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. Adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors. It possesses analgesic and respiratory depressive properties.sic and respiratory depressive properties.
, アドレノルフィン(Adrenorphin)は、内生の、C末端アミド化オピオイド(Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2)である。のタンパク質分解により生成し、哺乳類の脳に広く分布している。ヒトやウシの通常の脳にも存在するが、最初にヒトの副腎髄質(Adrenal medulla)の褐色細胞腫から検出されたということから名付けられた。アドレノルフィンは、とには作用するが、には作用しない、強いオピオイド活性を示す。呼吸抑制や鎮痛の効果を持つ。
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| rdfs:comment |
Adrenorphin, also sometimes referred to as … Adrenorphin, also sometimes referred to as metorphamide, is an endogenous, C-terminally amidated, opioid octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2, YGGFMRRV-NH2) that is produced from proteolytic cleavage of proenkephalin A and is widely distributed throughout the mammalian brain. It was named based on the fact that it was originally detected in human phaeochromocytoma tumour derived from the adrenal medulla, and was subsequently found in normal human and bovine adrenal medulla as well. Adrenorphin exhibits potent opioid activity, acting as a balanced μ- and κ-opioid receptor agonist while having no effects on δ-opioid receptors. It possesses analgesic and respiratory depressive properties.sic and respiratory depressive properties.
, アドレノルフィン(Adrenorphin)は、内生の、C末端アミド化オピオイド(Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2)である。のタンパク質分解により生成し、哺乳類の脳に広く分布している。ヒトやウシの通常の脳にも存在するが、最初にヒトの副腎髄質(Adrenal medulla)の褐色細胞腫から検出されたということから名付けられた。アドレノルフィンは、とには作用するが、には作用しない、強いオピオイド活性を示す。呼吸抑制や鎮痛の効果を持つ。
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Adrenorphin
, アドレノルフィン
|
